Literature DB >> 27470591

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34.

Jonathan M Backer1.   

Abstract

The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.
© 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Entities:  

Keywords:  Class III phosphoinositide 3-kinase; Vps34; autophagy; endocytosis; phosphoinositide 3-kinase; phosphorylation/dephosphorylation

Mesh：

Substances：

Year:  2016        PMID： 27470591     DOI： 10.1042/BCJ20160170

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  72 in total

Review 1.  LC3-associated phagocytosis at a glance.

Authors:  Bradlee L Heckmann; Douglas R Green
Journal:  J Cell Sci       Date:  2019-02-20       Impact factor: 5.285

2.  Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+ dendritic cells.

Authors:  Vrajesh V Parekh; Sudheer K Pabbisetty; Lan Wu; Eric Sebzda; Jennifer Martinez; Jianhua Zhang; Luc Van Kaer
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-17       Impact factor: 11.205

Review 3.  The PI3K Pathway in Human Disease.

Authors:  David A Fruman; Honyin Chiu; Benjamin D Hopkins; Shubha Bagrodia; Lewis C Cantley; Robert T Abraham
Journal:  Cell       Date:  2017-08-10       Impact factor: 41.582

4.  Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex.

Authors:  Goran Stjepanovic; Sulochanadevi Baskaran; Mary G Lin; James H Hurley
Journal:  Mol Cell       Date:  2017-07-27       Impact factor: 17.970

Review 5.  LC3-Associated Phagocytosis and Inflammation.

Authors:  Bradlee L Heckmann; Emilio Boada-Romero; Larissa D Cunha; Joelle Magne; Douglas R Green
Journal:  J Mol Biol       Date:  2017-08-25       Impact factor: 5.469

6.  Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics.

Authors:  Chunmei Chang; Lindsey N Young; Kyle L Morris; Sören von Bülow; Johannes Schöneberg; Hitomi Yamamoto-Imoto; Yukako Oe; Kentaro Yamamoto; Shuhei Nakamura; Goran Stjepanovic; Gerhard Hummer; Tamotsu Yoshimori; James H Hurley
Journal:  Mol Cell       Date:  2018-12-20       Impact factor: 17.970

Review 7.  Role of autophagy in MHC class I-restricted antigen presentation.

Authors:  Luc Van Kaer; Vrajesh V Parekh; J Luke Postoak; Lan Wu
Journal:  Mol Immunol       Date:  2017-11-08       Impact factor: 4.407

8.  Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex.

Authors:  Goran Stjepanovic; Sulochanadevi Baskaran; Mary G Lin; James H Hurley
Journal:  Mol Cell Oncol       Date:  2017-09-18

Review 9.  Autophagy and Hallmarks of Cancer.

Authors:  Tianzhi Huang; Xiao Song; Yongyong Yang; Xuechao Wan; Angel A Alvarez; Namratha Sastry; Haizhong Feng; Bo Hu; Shi-Yuan Cheng
Journal:  Crit Rev Oncog       Date:  2018

10.  A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

Authors:  Colin Valet; Marie Levade; Gaëtan Chicanne; Benoit Bilanges; Cendrine Cabou; Julien Viaud; Marie-Pierre Gratacap; Frédérique Gaits-Iacovoni; Bart Vanhaesebroeck; Bernard Payrastre; Sonia Severin
Journal:  Blood       Date:  2017-09-13       Impact factor: 22.113
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