Huan-Huan Yang1, Guo-Chong Chen2, Meng-Ge Zhou1, Li-Feng Xie1,3, Yuan-Yuan Jin1,4, Hao-Tian Chen1, Ze-Kun Chen1, Yu-Hao Kong1, Chang-Zheng Yuan5, Zhi-Hui Li6,7. 1. Vanke School of Public Health, Tsinghua University, Beijing, 100084, China. 2. Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China. 3. School of Human Nutrition, McGill University, Sainte-Anne-de-Bellevue, QC, Canada. 4. School of Nursing, University of Wisconsin-Madison, Madison, WI, USA. 5. School of Public Health, the Children's Hospital, and National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou, 310058, China. chy478@zju.edu.cn. 6. Vanke School of Public Health, Tsinghua University, Beijing, 100084, China. zhihuili@tsinghua.edu.cn. 7. Institute for Healthy China, Tsinghua University, Beijing, 100084, China. zhihuili@tsinghua.edu.cn.
Abstract
BACKGROUND: Numerous studies have suggested that age at first birth (AFB) is inversely associated with metabolic diseases, but positively associated with liver cancer in women. Non-alcoholic fatty liver disease (NAFLD) is a canonical example of metabolic dysfunction and inflammation-based liver disease, while the association between AFB and the risk of NAFLD remains unclear. We aimed to investigate the association between AFB and the odds of NAFLD in women. METHODS: Women older than 20 years at the time of the survey were analyzed using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018 in the US. AFB was obtained with self-administered questionnaires. NAFLD was diagnosed as fatty liver index (FLI) ≥ 60. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression models. RESULTS: Of the 12,188 women included in this study, 5670 (46.5%) had NAFLD. Compared to individuals with AFB of 30-32 years old (reference group), the fully adjusted ORs and 95% CI in women with AFB < 18, 18-20, 21-23, and 24-26 years were 1.52 (95% CI 1.14, 2.03), 1.60 (95% CI 1.21, 2.11), 1.40 (95% CI 1.06, 1.84), and 1.33 (95% CI 1.01-1.76), respectively. Yet there was no significant difference between AFB of 27-29, 33-35, or > 35 years compared to the reference group. CONCLUSIONS: Women with younger AFB have higher odds of NAFLD in later life. Policymakers should consider focusing on those with earlier AFB for screening and prevention of NAFLD.
BACKGROUND: Numerous studies have suggested that age at first birth (AFB) is inversely associated with metabolic diseases, but positively associated with liver cancer in women. Non-alcoholic fatty liver disease (NAFLD) is a canonical example of metabolic dysfunction and inflammation-based liver disease, while the association between AFB and the risk of NAFLD remains unclear. We aimed to investigate the association between AFB and the odds of NAFLD in women. METHODS: Women older than 20 years at the time of the survey were analyzed using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018 in the US. AFB was obtained with self-administered questionnaires. NAFLD was diagnosed as fatty liver index (FLI) ≥ 60. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression models. RESULTS: Of the 12,188 women included in this study, 5670 (46.5%) had NAFLD. Compared to individuals with AFB of 30-32 years old (reference group), the fully adjusted ORs and 95% CI in women with AFB < 18, 18-20, 21-23, and 24-26 years were 1.52 (95% CI 1.14, 2.03), 1.60 (95% CI 1.21, 2.11), 1.40 (95% CI 1.06, 1.84), and 1.33 (95% CI 1.01-1.76), respectively. Yet there was no significant difference between AFB of 27-29, 33-35, or > 35 years compared to the reference group. CONCLUSIONS: Women with younger AFB have higher odds of NAFLD in later life. Policymakers should consider focusing on those with earlier AFB for screening and prevention of NAFLD.
Authors: Nisha I Parikh; Rebecca P Jeppson; Jeffrey S Berger; Charles B Eaton; Candyce H Kroenke; Erin S LeBlanc; Cora E Lewis; Eric B Loucks; Donna R Parker; Eileen Rillamas-Sun; Kelli K Ryckman; Molly E Waring; Robert S Schenken; Karen C Johnson; Anna-Karin Edstedt-Bonamy; Matthew A Allison; Barbara V Howard Journal: Circulation Date: 2016-04-19 Impact factor: 29.690
Authors: Jeong Han Sim; Dawn Chung; Jung Soo Lim; Mi Young Lee; Choon Hee Chung; Jang Yel Shin; Ji Hye Huh Journal: PLoS One Date: 2015-05-26 Impact factor: 3.240