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Literature DB >> 3621345

A bacteriophage RNA polymerase transcribes in vitro through a nucleosome core without displacing it.

Abstract

Small linear DNA molecules containing histone octamers (nucleosome cores) are transcribed by SP6 RNA polymerase with only slightly lower efficiency than naked DNA templates. The position of the histone octamer on the DNA remains unchanged even after multiple passages by the polymerase. The histone octamer is not released even transiently from the DNA by polymerase transit. We conclude that histone octamers do not impede transcription elongation.

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Year: 1987 PMID： 3621345 DOI： 10.1016/0092-8674(87)90338-2

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

44 in total

1. Effects of histone tail domains on the rate of transcriptional elongation through a nucleosome.

Authors: R U Protacio; G Li; P T Lowary; J Widom
Journal: Mol Cell Biol Date: 2000-12 Impact factor: 4.272

2. Upstream activation sequence-dependent alteration of chromatin structure and transcription activation of the yeast GAL1-GAL10 genes.

Authors: M J Fedor; R D Kornberg
Journal: Mol Cell Biol Date: 1989-04 Impact factor: 4.272

3. Displacement of Xenopus transcription factor IIIA from a 5S rRNA gene by a transcribing RNA polymerase.

Authors: F E Campbell; D R Setzer
Journal: Mol Cell Biol Date: 1991-08 Impact factor: 4.272

Review 4. Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene control.

Authors: L P Villarreal
Journal: Microbiol Rev Date: 1991-09

5. Characterization of elongating T7 and SP6 RNA polymerases and their response to a roadblock generated by a site-specific DNA binding protein.

Authors: P A Pavco; D A Steege
Journal: Nucleic Acids Res Date: 1991-09-11 Impact factor: 16.971

A bacteriophage RNA polymerase transcribes in vitro through a nucleosome core without displacing it.

1. Effects of histone tail domains on the rate of transcriptional elongation through a nucleosome.

2. Upstream activation sequence-dependent alteration of chromatin structure and transcription activation of the yeast GAL1-GAL10 genes.

3. Displacement of Xenopus transcription factor IIIA from a 5S rRNA gene by a transcribing RNA polymerase.

Review 4. Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene control.

5. Characterization of elongating T7 and SP6 RNA polymerases and their response to a roadblock generated by a site-specific DNA binding protein.

Review 6. On the biological role of histone acetylation.

7. Glucocorticoid receptor DNA-binding specificity is increased by the organization of DNA in nucleosomes.

8. Nucleosomes on linear duplex DNA allow homologous pairing but prevent strand exchange promoted by RecA protein.

9. A role for RNA synthesis in homologous pairing events.

10. The effects of transcription on the nucleosome structure of four Dictyostelium genes.