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Literature DB >> 36185466

Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs.

S O Kushch¹, M V Goryaeva¹, Ya V Burgart¹, G A Triandafilova², K O Malysheva², O P Krasnykh², N A Gerasimova³, N P Evstigneeva³, V I Saloutin¹.

Abstract

The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity. © Springer Science+Business Media LLC 2022.

Entities: Chemical

Keywords: 3-polyfluoroalkyl-3-oxopropanoates; 4-(trifluoromethyl)pyridin-2-ones; ammonium acetate; ethyl trifluoroacetoacetate; methyl ketones; three-component reaction

Year: 2022 PMID： 36185466 PMCID： PMC9510450 DOI： 10.1007/s11172-022-3579-y

Source DB: PubMed Journal: Russ Chem Bull ISSN： 1066-5285 Impact factor: 1.704

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