Literature DB >> 36177383

High Dose Intravenous Vitamin C Treatment for Zika Fever.

Michael J Gonzalez1, Miguel J Berdiel2, Jorgé R Miranda-Massari2, Jorgé Duconge1, Joshua L Rodríguez-López3, Pedro A Adrover-López3.   

Abstract

The Zika Fever is a viral disease caused by a single-stranded RNA virus from the Flavivirus genus, Flaviviridae family, from the Spondweni group. Its transmission occurs through mosquito vectors, principally Aedes Aegypti. The most common symptoms of Zika are fever, rash, joint pain, and conjunctivitis (red eyes). Other common symptoms include muscle pain and headache. As of now, no vaccine exists for the virus and no official treatment has been developed aside from standard procedures of the use of acetaminophen (paracetamol) and non-steroidal anti-inflammatory drugs. This is a case report of a 54 year-old Hispanic female who arrived at the clinic with symptomatology congruent with the Zika fever. The patient was treated with high doses of intravenous vitamin C over three days. The symptoms resolved after the infusions without any side effects at day four. Recovery from this viral infection takes normally around two weeks. Based on the positive outcome in this case, we propose that intravenous vitamin C should be studied further as a potential treatment for acute viral infections.

Entities:  

Year:  2016        PMID: 36177383      PMCID: PMC9518686     

Source DB:  PubMed          Journal:  J Orthomol Med        ISSN: 0834-4825


  17 in total

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Authors:  S J Weiss
Journal:  N Engl J Med       Date:  1989-02-09       Impact factor: 91.245

Review 2.  Neutrophils, host defense, and inflammation: a double-edged sword.

Authors:  J A Smith
Journal:  J Leukoc Biol       Date:  1994-12       Impact factor: 4.962

Review 3.  Antioxidants: potential antiviral agents for Japanese encephalitis virus infection.

Authors:  Yu Zhang; Zehua Wang; Huan Chen; Zongtao Chen; Yanping Tian
Journal:  Int J Infect Dis       Date:  2014-04-26       Impact factor: 3.623

4.  One-step RT-PCR for detection of Zika virus.

Authors:  Oumar Faye; Ousmane Faye; Anne Dupressoir; Manfred Weidmann; Mady Ndiaye; Amadou Alpha Sall
Journal:  J Clin Virol       Date:  2008-07-31       Impact factor: 3.168

5.  Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study.

Authors:  Van-Mai Cao-Lormeau; Alexandre Blake; Sandrine Mons; Stéphane Lastère; Claudine Roche; Jessica Vanhomwegen; Timothée Dub; Laure Baudouin; Anita Teissier; Philippe Larre; Anne-Laure Vial; Christophe Decam; Valérie Choumet; Susan K Halstead; Hugh J Willison; Lucile Musset; Jean-Claude Manuguerra; Philippe Despres; Emmanuel Fournier; Henri-Pierre Mallet; Didier Musso; Arnaud Fontanet; Jean Neil; Frédéric Ghawché
Journal:  Lancet       Date:  2016-03-02       Impact factor: 79.321

Review 6.  Zika Virus: Diagnostics for an Emerging Pandemic Threat.

Authors:  Jesse J Waggoner; Benjamin A Pinsky
Journal:  J Clin Microbiol       Date:  2016-02-17       Impact factor: 5.948

7.  Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013.

Authors:  E Oehler; L Watrin; P Larre; I Leparc-Goffart; S Lastere; F Valour; L Baudouin; Hp Mallet; D Musso; F Ghawche
Journal:  Euro Surveill       Date:  2014-03-06

8.  The Emergence of Zika Virus as a Global Health Security Threat: A Review and a Consensus Statement of the INDUSEM Joint working Group (JWG).

Authors:  Veronica Sikka; Vijay Kumar Chattu; Raaj K Popli; Sagar C Galwankar; Dhanashree Kelkar; Stanley G Sawicki; Stanislaw P Stawicki; Thomas J Papadimos
Journal:  J Glob Infect Dis       Date:  2016 Jan-Mar

9.  Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection.

Authors:  Yejin Kim; Hyemin Kim; Seyeon Bae; Jiwon Choi; Sun Young Lim; Naeun Lee; Joo Myung Kong; Young-Il Hwang; Jae Seung Kang; Wang Jae Lee
Journal:  Immune Netw       Date:  2013-04-30       Impact factor: 6.303

10.  Effect of high-dose intravenous vitamin C on inflammation in cancer patients.

Authors:  Nina Mikirova; Joseph Casciari; Andrea Rogers; Paul Taylor
Journal:  J Transl Med       Date:  2012-09-11       Impact factor: 5.531

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