Literature DB >> 36166705

Investigating protein-excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy.

Jainik Panchal1, Bradley T Falk2, Valentyn Antochshuk1, Mark A McCoy2.   

Abstract

ALPHABETICAL LIST OF ABBREVIATIONS: Fab Fragment antigen-binding; Fc Fragment crystallizable; HMW High molecular weight; ∆HMW Difference between HMW species at stress temperature and 5°C controls; IgG Immunoglobulin G; mAbs Monoclonal antibodies; MV-VHH Multivalent VHH molecule with the format aC-L1-aC-L1-aD; NMR Nuclear magnetic resonance; scFv Single-chain fragment variable; SEC Size-exclusion chromatography; VHH Variable domain of Heavy chain of Heavy chain-only antibody.

Entities:  

Keywords:  NMR profiling; developability; formulation; multivalent multi-domain proteins; protein solution interactions; protein–excipient interactions; stabilization

Mesh：

Substances：

Year:  2022        PMID： 36166705      PMCID： PMC9519013          DOI： 10.1080/19420862.2022.2124902

Source DB:  PubMed          Journal:  MAbs        ISSN： 1942-0862            Impact factor:   6.440


  33 in total

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6.  Understanding the Role of Preferential Exclusion of Sugars and Polyols from Native State IgG1 Monoclonal Antibodies and its Effect on Aggregation and Reversible Self-Association.

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8.  Preferential interactions of proteins with salts in concentrated solutions.

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Journal:  Biochemistry       Date:  1982-12-07       Impact factor: 3.162

9.  SWISS-MODEL: homology modelling of protein structures and complexes.

Authors:  Andrew Waterhouse; Martino Bertoni; Stefan Bienert; Gabriel Studer; Gerardo Tauriello; Rafal Gumienny; Florian T Heer; Tjaart A P de Beer; Christine Rempfer; Lorenza Bordoli; Rosalba Lepore; Torsten Schwede
Journal:  Nucleic Acids Res       Date:  2018-07-02       Impact factor: 16.971

10.  Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using 1H NMR Spectroscopy.

Authors:  Jack E Bramham; Adrian Podmore; Stephanie A Davies; Alexander P Golovanov
Journal:  ACS Pharmacol Transl Sci       Date:  2020-12-16
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