Literature DB >> 36151402

Immune disguise: the mechanisms of Neu5Gc inducing autoimmune and transplant rejection.

Fadian Ding1,2, Yunfeng Lin3, Guozhong Liu1, Yuxin Liu4, Feng Gao5, Qicai Liu6,7, Zhibo Zhang8,9, Shangeng Weng10,11.   

Abstract

Organ (stem cell) transplantation is the most effective treatment for advanced organ failure. Neu5Gc (N-hydroxyacetylneuraminic acid) is a pathogenic non-human sialic acid, which is very similar to the molecular structure of Neu5Ac (N-acetylneuraminic acid) in human body. Neu5Gc has the function of "immune disguise", which is the main obstacle to transplantation. Gene knockout such as cytidine monophosphate-N-acetylneuraminidase (CMAH) reduces donor antigenicity, making xenotransplantation from fiction to reality. Exploring the immune disguise event in this emerging field has become a hot topic in the research of transplantation immune tolerance mechanism.
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Year:  2022        PMID： 36151402     DOI： 10.1038/s41435-022-00182-8

Source DB:  PubMed          Journal:  Genes Immun        ISSN： 1466-4879            Impact factor:   4.248


  68 in total

Review 1.  In Search of the Ideal Valve: Optimizing Genetic Modifications to Prevent Bioprosthetic Degeneration.

Authors:  Benjamin Smood; Hidetaka Hara; David C Cleveland; David K C Cooper
Journal:  Ann Thorac Surg       Date:  2019-03-02       Impact factor: 4.330

2.  PIRs mediate innate myeloid cell memory to nonself MHC molecules.

Authors:  Hehua Dai; Peixiang Lan; Daqiang Zhao; Khodor Abou-Daya; Wentao Liu; Wenhao Chen; Andrew J Friday; Amanda L Williams; Tao Sun; Jianjiao Chen; Wei Chen; Steven Mortin-Toth; Jayne S Danska; Chris Wiebe; Peter Nickerson; Tengfang Li; Lisa R Mathews; Hêth R Turnquist; Matthew L Nicotra; Sebastien Gingras; Eiji Takayama; Hiromi Kubagawa; Mark J Shlomchik; Martin H Oberbarnscheidt; Xian C Li; Fadi G Lakkis
Journal:  Science       Date:  2020-05-07       Impact factor: 47.728

3.  Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms.

Authors:  Kunio Kawanishi; Chirag Dhar; Raymond Do; Nissi Varki; Philip L S M Gordts; Ajit Varki
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-22       Impact factor: 11.205

4.  Human antibody reactivity against xenogeneic N-glycolylneuraminic acid and galactose-α-1,3-galactose antigen.

Authors:  Sunghoon Hurh; Bohae Kang; Inho Choi; Bumrae Cho; Eun Mi Lee; Hwajung Kim; Young June Kim; Yun Shin Chung; Jong Cheol Jeong; Jong-Ik Hwang; Jae Young Kim; Byeong Chun Lee; Charles D Surh; Jaeseok Yang; Curie Ahn
Journal:  Xenotransplantation       Date:  2016-07-04       Impact factor: 3.907

5.  Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH.

Authors:  Runjie Zhang; Ying Wang; Lei Chen; Ronggen Wang; Chu Li; Xiaoxue Li; Bin Fang; Xueyang Ren; Miaomiao Ruan; Jiying Liu; Qiang Xiong; Lining Zhang; Yong Jin; Manling Zhang; Xiaorui Liu; Lin Li; Qiang Chen; Dengke Pan; Rongfeng Li; David K C Cooper; Haiyuan Yang; Yifan Dai
Journal:  Acta Biomater       Date:  2018-04-07       Impact factor: 8.947

6.  A Mouse Model for Dietary Xenosialitis: ANTIBODIES TO XENOGLYCAN CAN REDUCE FERTILITY.

Authors:  Fang Ma; Liwen Deng; Patrick Secrest; Linda Shi; June Zhao; Pascal Gagneux
Journal:  J Biol Chem       Date:  2016-07-05       Impact factor: 5.157

7.  Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution.

Authors:  Hsun-Hua Chou; Toshiyuki Hayakawa; Sandra Diaz; Matthias Krings; Etty Indriati; Meave Leakey; Svante Paabo; Yoko Satta; Naoyuki Takahata; Ajit Varki
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-21       Impact factor: 11.205

8.  Small RNAs are modified with N-glycans and displayed on the surface of living cells.

Authors:  Ryan A Flynn; Kayvon Pedram; Stacy A Malaker; Pedro J Batista; Benjamin A H Smith; Alex G Johnson; Benson M George; Karim Majzoub; Peter W Villalta; Jan E Carette; Carolyn R Bertozzi
Journal:  Cell       Date:  2021-05-17       Impact factor: 66.850

Review 9.  "You cannot stay in the laboratory forever"*: Taking pig kidney xenotransplantation from the laboratory to the clinic.

Authors:  David K C Cooper; Hidetaka Hara
Journal:  EBioMedicine       Date:  2021-09-10       Impact factor: 8.143

10.  Extensive germline genome engineering in pigs.

Authors:  Yanan Yue; Weihong Xu; Yinan Kan; Hong-Ye Zhao; Yixuan Zhou; Xiaobin Song; Jiajia Wu; Juan Xiong; Dharmendra Goswami; Meng Yang; Lydia Lamriben; Mengyuan Xu; Qi Zhang; Yu Luo; Jianxiong Guo; Shengyi Mao; Deling Jiao; Tien Dat Nguyen; Zhuo Li; Jacob V Layer; Mailin Li; Violette Paragas; Michele E Youd; Zhongquan Sun; Yuan Ding; Weilin Wang; Hongwei Dou; Lingling Song; Xueqiong Wang; Lei Le; Xin Fang; Haydy George; Ranjith Anand; Shi Yun Wang; William F Westlin; Marc Güell; James Markmann; Wenning Qin; Yangbin Gao; Hong-Jiang Wei; George M Church; Luhan Yang
Journal:  Nat Biomed Eng       Date:  2020-09-21       Impact factor: 25.671
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