Literature DB >> 3614016

Glutathione: is it an evolutionary vestige of the penicillins?

J E Spallholz.   

Abstract

Glutathione is structurally similar to the precursor of the antibiotics found in the fungi of the genus Penicillium and Cephalosporium. The structural similarity is such to permit the rearrangement of glutathione to form the beta-lactam ring, common to many antibiotics. The possibility exists that glutathione may have evolved away from an antibiotic role in cells with the evolutionary development of specialized cells of immune systems.

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Year:  1987        PMID: 3614016     DOI: 10.1016/0306-9877(87)90016-8

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  4 in total

1.  A peptide permease mutant of Mycobacterium bovis BCG resistant to the toxic peptides glutathione and S-nitrosoglutathione.

Authors:  R M Green; A Seth; N D Connell
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

2.  Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis.

Authors:  Vishwanath Venketaraman; Yaswant K Dayaram; Meliza T Talaue; Nancy D Connell
Journal:  Infect Immun       Date:  2005-03       Impact factor: 3.441

3.  Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione.

Authors:  Yaswant K Dayaram; Meliza T Talaue; Nancy D Connell; Vishwanath Venketaraman
Journal:  J Bacteriol       Date:  2006-02       Impact factor: 3.490

Review 4.  Mechanisms of Control of Mycobacterium tuberculosis by NK Cells: Role of Glutathione.

Authors:  Michael Allen; Cedric Bailey; Ian Cahatol; Levi Dodge; Jay Yim; Christine Kassissa; Jennifer Luong; Sarah Kasko; Shalin Pandya; Vishwanath Venketaraman
Journal:  Front Immunol       Date:  2015-10-05       Impact factor: 7.561

  4 in total

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