Anaïs Moravia1,2, Serge Simoëns3, Mahmoud El Hajem3, Benyebka Bou-Saïd4, Marine Menut5, Pascale Kulisa3, Patrick Lermusiaux6, Nellie Della-Schiava6. 1. Université de Lyon, INSA de Lyon, Ecole Centrale de Lyon, Université Claude Bernard Lyon 1, CNRS, LMFA UMR 5509, Villeurbanne, France. anais.moravia@ec-lyon.fr. 2. Ecole Centrale Lyon, LMFA, 36 avenue Guy de Collongue, 69134, Ecully, France. anais.moravia@ec-lyon.fr. 3. Université de Lyon, INSA de Lyon, Ecole Centrale de Lyon, Université Claude Bernard Lyon 1, CNRS, LMFA UMR 5509, Villeurbanne, France. 4. Université de Lyon, CNRS, INSA de Lyon, LaMCoS UMR5259, Villeurbanne, France. 5. CISTEN, 66 Bd. N. Bohr, CS 52132, 69603, Villeurbanne, France. 6. Vascular and Endovascular Department, Hospices Civils de Lyon, Lyon, France.
Abstract
PURPOSE: Pulse wave velocity (PWV) is an indicator of arterial stiffness used in the prediction of cardiovascular disease such as atherosclerosis. Non-invasive methods performed with ultrasound probes allow one to compute PWV and aortic stiffness through the measurement of the aortic diameter (D) and blood flow velocity (U) with the lnD-U method. This technique based on in vivo acquisitions lacks validation since the aortic elasticity modulus cannot be verified with mechanical strength tests. METHOD: In the present study, an alternative validation is carried out on an aorta phantom hosted in an aortic flow simulator which mimics pulsatile inflow conditions. This in vitro setup included a Particle Image Velocimetry device to visualize flow in a 2D longitudinal section of the phantom, compute velocity fields (U), and track wall displacements in the aorta phantom to measure the apparent diameter (AD) variations throughout cycles. RESULTS: The lnD-U method was then applied to evaluate PWV (5.79 ± 0.33 m/s) and calculate the Young's modulus of the aorta phantom (0.56 ± 0.12 MPa). This last value was compared to the elasticity modulus (0.53 ± 0.07 MPa) evaluated with tensile strength tests on samples cut from the silicone phantom. CONCLUSION: The PIV technique PWV measurement showed good agreement with the direct tensile test method with a 5.6% difference in Young's modulus. Considering the uncertainties from the two methods, the measured elasticities are consistent and close to a 50-60 years old male aortic behavior. The choice of silicone for the phantom material is a relevant and promising option to mimic the human aorta on in vitro systems.
PURPOSE: Pulse wave velocity (PWV) is an indicator of arterial stiffness used in the prediction of cardiovascular disease such as atherosclerosis. Non-invasive methods performed with ultrasound probes allow one to compute PWV and aortic stiffness through the measurement of the aortic diameter (D) and blood flow velocity (U) with the lnD-U method. This technique based on in vivo acquisitions lacks validation since the aortic elasticity modulus cannot be verified with mechanical strength tests. METHOD: In the present study, an alternative validation is carried out on an aorta phantom hosted in an aortic flow simulator which mimics pulsatile inflow conditions. This in vitro setup included a Particle Image Velocimetry device to visualize flow in a 2D longitudinal section of the phantom, compute velocity fields (U), and track wall displacements in the aorta phantom to measure the apparent diameter (AD) variations throughout cycles. RESULTS: The lnD-U method was then applied to evaluate PWV (5.79 ± 0.33 m/s) and calculate the Young's modulus of the aorta phantom (0.56 ± 0.12 MPa). This last value was compared to the elasticity modulus (0.53 ± 0.07 MPa) evaluated with tensile strength tests on samples cut from the silicone phantom. CONCLUSION: The PIV technique PWV measurement showed good agreement with the direct tensile test method with a 5.6% difference in Young's modulus. Considering the uncertainties from the two methods, the measured elasticities are consistent and close to a 50-60 years old male aortic behavior. The choice of silicone for the phantom material is a relevant and promising option to mimic the human aorta on in vitro systems.
Authors: Daniel G H Devos; Ernst Rietzschel; Catherine Heyse; Pieter Vandemaele; Luc Van Bortel; Danilo Babin; Patrick Segers; Jos M Westenberg; Rik Achten Journal: J Magn Reson Imaging Date: 2014-02-24 Impact factor: 4.813
Authors: Heynric B Grotenhuis; Jos J M Westenberg; Paul Steendijk; Rob J van der Geest; Jaap Ottenkamp; Jeroen J Bax; J Wouter Jukema; Albert de Roos Journal: J Magn Reson Imaging Date: 2009-09 Impact factor: 4.813
Authors: J Concannon; P Dockery; A Black; S Sultan; N Hynes; P E McHugh; K M Moerman; J P McGarry Journal: J Anat Date: 2019-09-11 Impact factor: 2.610