| Literature DB >> 36127470 |
Shuhui Yang1, Lei Liu1, Jingwen Wang2, Shuyu Guo1, Guorong Liu3, Xing Chen1, Xi Deng1, Mingxia Tu1, Yufei Tao1, Yu Rao4.
Abstract
The persistence of Staphylococcus aureus within biofilm can lead to contamination of medical devices and life-threatening infections. Luckily, lactic acid bacteria (LAB) have an inhibitory effect on the growth of these bacteria. This study aims to select LAB strains from fermented vegetables, and analyze their potential inhibition activities against S. aureus. In total, 45 isolates of LAB were successfully isolated from Sichuan pickles, and the CFS of Lactiplantibacillus plantarum LR-14 exerted the strongest inhibitory effect against S. aureus. Moreover, S. aureus cells in planktonic and biofilm states both wrinkled and damaged when treated with the CFS of L. plantarum LR-14. In addition, whole genome sequencing analysis indicates that L. plantarum LR-14 contains various functional genes, including predicted extracellular polysaccharides (EPS) biosynthesis genes, and genes participating in the synthesis and metabolism of fatty acid, implying that L. plantarum LR-14 has the potential to be used as a probiotic with multiple functions.Entities:
Keywords: Antibacterial activity; Biofilm; Genome sequencing; Lactiplantibacillus plantarum; Staphylococcus aureus
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Year: 2022 PMID： 36127470 DOI： 10.1007/s00203-022-03232-x
Source DB: PubMed Journal: Arch Microbiol ISSN： 0302-8933 Impact factor: 2.667