Literature DB >> 36124200

Ocular stem cells: a narrative review of current clinical trials.

Konstadinos Sotiropulos1, Dimitrios Kourkoutas2, Diamantis Almaliotis3, Katherine Ploumidou4, Vasileios Karampatakis3.   

Abstract

Stem cells are undifferentiated cells showcasing a remarkable capacity of self-replenishing and differentiating into mature cells. Their ability to proliferate connotes that a designated stem cell source is capable of generating an unrestricted number of mature cells. The ever-increasing comprehension of position, activity, and function of ocular stem cells has led to rapid progress and incessant improvement of possible procedures and therapies. A narrative review was conducted to summarize the current evidence on clinical trials and respective literature, regarding current evolution in the field of ocular regenerative medicine. We tried to ascertain the safety of experimental and clinical procedures, their effectiveness, and the ethical repercussion of their use. International Journal of Ophthalmology Press.

Entities:  

Keywords:  cell-based therapies; hESC-derived retinal pigment epithelium; human induced pluripotent stem cells; limbal stem cells; olfactory mucosa mesenchymal stem cells; stem cells

Year:  2022        PMID: 36124200      PMCID: PMC9453397          DOI: 10.18240/ijo.2022.09.17

Source DB:  PubMed          Journal:  Int J Ophthalmol        ISSN: 2222-3959            Impact factor:   1.645


  73 in total

1.  Visual function 5 years or more after macular translocation surgery for myopic choroidal neovascularisation and age-related macular degeneration.

Authors:  K Takeuchi; S Kachi; E Iwata; K Ishikawa; H Terasaki
Journal:  Eye (Lond)       Date:  2011-12-16       Impact factor: 3.775

2.  Prospects for stem cell-based therapy.

Authors:  George Q Daley; David T Scadden
Journal:  Cell       Date:  2008-02-22       Impact factor: 41.582

3.  Stem cells and drug discovery: the beginning of a new era?

Authors:  Lee L Rubin
Journal:  Cell       Date:  2008-02-22       Impact factor: 41.582

Review 4.  Stem Cell Therapies in Clinical Trials: Progress and Challenges.

Authors:  Alan Trounson; Courtney McDonald
Journal:  Cell Stem Cell       Date:  2015-07-02       Impact factor: 24.633

5.  Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry.

Authors:  Leigh Turner; Paul Knoepfler
Journal:  Cell Stem Cell       Date:  2016-06-30       Impact factor: 24.633

6.  CEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathies.

Authors:  Rivka A Rachel; Erin A Yamamoto; Mrinal K Dewanjee; Helen L May-Simera; Yuri V Sergeev; Alice N Hackett; Katherine Pohida; Jeeva Munasinghe; Norimoto Gotoh; Bill Wickstead; Robert N Fariss; Lijin Dong; Tiansen Li; Anand Swaroop
Journal:  Hum Mol Genet       Date:  2015-04-09       Impact factor: 6.150

7.  Transplantation of cultured olfactory mucosal cells rescues optic nerve axons in a rat glaucoma model.

Authors:  Chao Dai; Jing Xie; Jiaman Dai; Daqing Li; Peng T Khaw; Zhengqin Yin; Shujia Huo; Andrew Collins; Geoffrey Raisman; Ying Li
Journal:  Brain Res       Date:  2019-02-13       Impact factor: 3.252

8.  Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies.

Authors:  Steven D Schwartz; Carl D Regillo; Byron L Lam; Dean Eliott; Philip J Rosenfeld; Ninel Z Gregori; Jean-Pierre Hubschman; Janet L Davis; Gad Heilwell; Marc Spirn; Joseph Maguire; Roger Gay; Jane Bateman; Rosaleen M Ostrick; Debra Morris; Matthew Vincent; Eddy Anglade; Lucian V Del Priore; Robert Lanza
Journal:  Lancet       Date:  2014-10-15       Impact factor: 79.321

9.  Limbal autograft transplantation for ocular surface disorders.

Authors:  K R Kenyon; S C Tseng
Journal:  Ophthalmology       Date:  1989-05       Impact factor: 12.079

10.  Differentiation of human olfactory mucosa mesenchymal stem cells into photoreceptor cells in vitro.

Authors:  Wen Lu; Da Duan; Zacharia Ackbarkhan; Ming Lu; Min-Li Huang
Journal:  Int J Ophthalmol       Date:  2017-10-18       Impact factor: 1.779

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