Luca Nicosia1, Germana Lissidini2, Manuela Sargenti2, Anna Carla Bozzini3, Gabriel Farante2, José Vila4, Chiara Oriecuia5,6, Eleonora Pagan7, Vincenzo Bagnardi7, Matteo Lazzeroni8, Filippo Pesapane3, Claudia Sangalli9, Viviana Galimberti2, Enrico Cassano3, Paolo Veronesi10,11. 1. Department of Breast Radiology, European Institute of Oncology (IEO), IRCCS, 20141, Milan, Italy. luca.nicosia@ieo.it. 2. Division of Breast Surgery, European Institute of Oncology (IEO), IRCCS, Milan, Italy. 3. Department of Breast Radiology, European Institute of Oncology (IEO), IRCCS, 20141, Milan, Italy. 4. Hospital Universitario y Politécnico La Fe, Valencia, Spain. 5. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. 6. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. 7. Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy. 8. Division of Cancer Prevention and Genetics, European Institute of Oncology (IEO), IRCCS, Milan, Italy. 9. Data Management, European Institute of Oncology IRCCS, 20141, Milan, Italy. 10. Division of Breast Surgery, European Institute of Oncology (IEO), IRCCS, Milan, Italy. paolo.veronesi@ieo.it. 11. Department of Oncology and Hemato-Oncology, University of Milan, 20133, Milan, Italy. paolo.veronesi@ieo.it.
Abstract
PURPOSE: To present an overview of the management of male patients with Ductal Carcinoma In Situ of the breast (male DCIS). METHODS: We retrospectively studied all male patients with a diagnosis of pure DCIS from January 1999 to December 2018: 20 patients were identified in our cancer referral center. We collected data regarding clinical presentation, age of onset, radiological features, receptor status of the neoplasm, histological type, and the follow-up of those patients. RESULTS: The median age was 62 years (range 21-80). All patients underwent surgery, in 15/20 (75%) cases a mastectomy was carried out. Two patients (10%) underwent endocrine treatment and 1/20 (5%) underwent radiotherapy. The receptor status for 15/20 patients was documented: 13/15 patients were ER+/Pr+. In 3 cases the Ki 67% was positive (i.e., > 20%). All cases were negative for Her2. The median follow-up time was 9.0 years (IQR 4.0-13.7). Only one patient had an ipsilateral recurrence with the finding of an infiltrating carcinoma in the same breast after 14 years. The 5-year disease-free survival was 92.9%. CONCLUSION: Pure DCIS in men is an extremely rare disease: proper diagnosis and management allow an excellent prognosis.
PURPOSE: To present an overview of the management of male patients with Ductal Carcinoma In Situ of the breast (male DCIS). METHODS: We retrospectively studied all male patients with a diagnosis of pure DCIS from January 1999 to December 2018: 20 patients were identified in our cancer referral center. We collected data regarding clinical presentation, age of onset, radiological features, receptor status of the neoplasm, histological type, and the follow-up of those patients. RESULTS: The median age was 62 years (range 21-80). All patients underwent surgery, in 15/20 (75%) cases a mastectomy was carried out. Two patients (10%) underwent endocrine treatment and 1/20 (5%) underwent radiotherapy. The receptor status for 15/20 patients was documented: 13/15 patients were ER+/Pr+. In 3 cases the Ki 67% was positive (i.e., > 20%). All cases were negative for Her2. The median follow-up time was 9.0 years (IQR 4.0-13.7). Only one patient had an ipsilateral recurrence with the finding of an infiltrating carcinoma in the same breast after 14 years. The 5-year disease-free survival was 92.9%. CONCLUSION: Pure DCIS in men is an extremely rare disease: proper diagnosis and management allow an excellent prognosis.
Authors: Lars J Grimm; Stamatia V Destounis; Habib Rahbar; Mary Scott Soo; Steven P Poplack Journal: J Am Coll Radiol Date: 2020-04-09 Impact factor: 5.532
Authors: Augusto Lombardi; Rachele Lazzeroni; Laura Bersigotti; Valeria Vitale; Claudio Amanti Journal: Breast Cancer (Dove Med Press) Date: 2021-04-07