Asymptomatic Incidental Ductal Carcinoma in situ in a Male Breast Presenting with Contralateral Gynecomastia.

Ductal carcinoma in situ (DCIS) in males is rare and usually presents with symptoms on the affected side, such as, palpable mass or bloody nipple discharge. Even as DCIS has been reported in conjunction with gynecomastia in the same breast, we report an unusual case of a 62-year-old Caucasian male, with no family history of breast cancer, who presented with symptomatic side gynecomastia, and was incidentally found to have DCIS in a completely asymptomatic left breast. To the best of our knowledge, this case is the first report in literature of asymptomatic, incidentally discovered DCIS in a male patient.

INTRODUCTION

Gynecomastia is an over-development of the glandular tissue of the breast region in males. This is different from fat deposits in the breast area seen in obese men. It occurs in young boys during puberty and in older men and results from an imbalance in the hormone levels. This is a benign condition. Breast cancer in men is uncommon. Coexistence of gynecomastia and ductal carcinoma, though rare, has been reported in literature.

CASE REPORT

A 62-year-old Caucasian male presented with a complaint of pain and swelling in the retroareolar right breast. The left breast was asymptomatic. The patient denied any family history of breast cancer and had no history of trauma to the breast. His only medication was Ritalin.

The patient underwent a bilateral digital diagnostic mammogram with mediolateral oblique (MLO) and craniocaudal (CC) views of both breasts (Hologic Lorad Selenia). The breasts showed scant fibroglandular tissue consistent with male breasts. There was a flame-shaped density within the retroareolar right breast consistent with mammographic gynecomastia. There was no evidence of gynecomastia in the left breast [Figure 1]. Further evaluation with ultrasound was recommended for confirmation and to evaluate for any underlying mass. Additional magnification views of the left breast were performed for regional retroareolar pleomorphic and linear microcalcifications extending to the upper outer quadrant [Figure 2]. These microcalcifications were suspicious, and given the regional distribution, further evaluation with ultrasound was recommended to evaluate for any associated mass. There were no additional suspicious masses, microcalcifications, or areas of architectural distortion in either breast.

Figure 1

Medial lateral oblique and craniocaudal views of the bilateral breasts show flame-shaped gynecomastia of the right breast. The left breast shows microcalcifcations (arrows) for which magnification views have been performed.

Figure 2

Medial lateral and craniocaudal magnification views of the left breast show suspicious microcalcifications in the retroareolar region extending to the upper outer quadrant (arrows).

An ultrasound examination of both breasts was performed utilizing a 12 MHz transducer (Toshiba Alplio MX). The area of pain and retroareolar density in the right breast seen on mammogram corresponded to vague heterogeneous glandular tissue, consistent with gynecomastia, by ultrasound [Figure 3]. No sonographic abnormality was noted in the area of regional microcalcifications in the left breast. Normal left axillary lymph nodes were present.

Figure 3

Transverse ultrasound image of the right breast demonstrating retroareolar glandular tissue consistent with gynecomastia. No suspicious masses were identified in the right breast.

The patient subsequently underwent stereotactic core biopsy (9 gauge Suros Eviva) of the suspicious microcalcifications in the left breast. Pathology results showed ductal carcinoma in situ grade II, with intermediate nuclear grade features in multiple core fragments [Figure 4]. Estrogen and progesterone receptors were positive. The patient was treated with left total mastectomy and sentinel lymph node biopsy, which was negative. Surgical pathology confirmed DCIS nuclear grade II (intermediate), with all surgical margins uninvolved by DCIS.

Figure 4

Microscopic findings. (a) Ductal carcinoma in situ with intraductal proliferation of small, monomorphic cells, forming secondary microlumina, with clustered microcalcifications (hematoxylin and eosin stain) (4×). (b) Punctate necrosis is present in some involved ducts (hematoxylin and eosin stain) (4×). (c) Microcalcifications are present within the ducts and stroma (hematoxylin and eosin stain) (10×).

DISCUSSION

Most cases of male DCIS present with symptoms on the affected side, such as, palpable mass or bloody nipple discharge.[1] Our case is unusual in that the patient presented with symptoms of gynecomastia in the right breast, and the cancer was an incidental finding in the asymptomatic left breast. The patient was completely asymptomatic on the left with no pain, palpable mass or nipple discharge. Other authors have reported cases of concurrent gynecomastia and DCIS in the same breast, in male patients.[2-6]

Ductal carcinoma in situ of the male breast is rare, accounting for only about 7% of all male breast cancer cases.[1] Of all patients (male and female) with DCIS, 30 - 50% develop invasive cancer in the following 10 - 20 years, so the actual prevalence may be higher.[2] A vast majority of male breast cancers are ductal, and usually present late, with approximately 40% having stage III or IV disease.[4] Men are less likely than women to be diagnosed in the early stages, but diagnosis at the non-invasive stage has increased. This increase in early diagnosis may be due to improved awareness of male breast cancer. Factors that increase the risk of male breast cancer include high estrogen states, Klinefelter's syndrome, family history, BRCA 2 gene, hyperprotactinemia, and prior radiation.[78] No increased breast cancer risk associated with gynecomastia in males has been found.[24]

The exact cause of DCIS in males in unknown, as they lack the terminal duct lobular units where DCIS often originates in women. It is hypothesized, however, that DCIS originates in the duct epithelium in men.[2] Mammography for male breast cancer has a reported sensitivity of 92% and specificity of 91%.[9] Calcifications are less frequently associated with male breast cancer than female breast cancer. Malignant calcifications in the male breast often have a more benign appearance and can be more scattered or round.[910]

Management of male breast cancer is largely based on studies that deal with female breast cancer. Typical treatment for males with DCIS is total mastectomy without axillary node dissection.[18] In a series of 31 cases of pure DCIS in men by Cutuli et al., 19 cases underwent axillary node dissection, with all sampled lymph nodes negative.[3] Recurrence of male DCIS following total mastectomy has yet to be described.[2] In the same series of 31 cases of male DCIS, Cutuli et al., described only four recurrences, none of which were in patients treated with total mastectomy.[3] No further adjuvant therapy is necessary, and prognosis for DCIS in males is excellent.

Non-invasive breast cancers in men are symptomatic at presentation. For men, there is no standardized routine screening program for breast cancer. Our case emphasizes that the contralateral breast should also be imaged in males presenting with unilateral breast symptoms.