Literature DB >> 361144

Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix.

E R Watson, K E Halnan, S Dische, M I Saunders, I S Cade, J B McEwen, G Wiernik, D J Perrins, I Sutherland.   

Abstract

In a randomized controlled clinical trial of hyperbaric oxygen in the radiotherapy of advanced carcinoma of the uterine cervix a total of 320 cases were contributed by four radiotherapy centres in the United Kingdom. The use of hyperbaric oxygen resulted in improved local control and survival. The benefit was greatest in patients under the age of 55 who presented with stage III disease. There was a slight increase in radiation morbidity but it seemed that the benefit of hyperbaric oxygen outweighed this increase in morbidity and that there was a true improvement in the therapeutic ratio.

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Year:  1978        PMID: 361144     DOI: 10.1259/0007-1285-51-611-879

Source DB:  PubMed          Journal:  Br J Radiol        ISSN: 0007-1285            Impact factor:   3.039


  28 in total

1.  Hyperbaric oxygen therapy. Combination with radiotherapy in cancer is of proved benefit but rarely used.

Authors:  C Coles; M Williams; N Burnet
Journal:  BMJ       Date:  1999-04-17

2.  Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI.

Authors:  S W Young; F Qing; A Harriman; J L Sessler; W C Dow; T D Mody; G W Hemmi; Y Hao; R A Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

Review 3.  Role of hyperoxic treatment in cancer.

Authors:  Sei W Kim; In K Kim; Sang H Lee
Journal:  Exp Biol Med (Maywood)       Date:  2020-04-23

Review 4.  Molecular Pathways: A Novel Approach to Targeting Hypoxia and Improving Radiotherapy Efficacy via Reduction in Oxygen Demand.

Authors:  Alexander Lin; Amit Maity
Journal:  Clin Cancer Res       Date:  2015-05-01       Impact factor: 12.531

5.  A randomised study of ornidazole as a radiosensitiser in carcinoma of the cervix: long term results.

Authors:  S Okkan; G Atkovar; I Sahinler; S Turkan; R Uzel
Journal:  Br J Cancer Suppl       Date:  1996-07

6.  Oxygen distributions partly explain the radiation response of human squamous cell carcinomas.

Authors:  P Okunieff; J de Bie; E P Dunphy; D J Terris; M Höckel
Journal:  Br J Cancer Suppl       Date:  1996-07

Review 7.  Hyperbaric oxygen therapy for malignancy: a review.

Authors:  Jurstine Daruwalla; Chris Christophi
Journal:  World J Surg       Date:  2006-12       Impact factor: 3.352

8.  Interstitial diffuse optical probe with spectral fitting to measure dynamic tumor hypoxia.

Authors:  Leonard Che Fru; Steven L Jacques; Kwang P Nickel; Tomy Varghese; Michael W Kissick; Larry A DeWerd; Randall J Kimple
Journal:  Biomed Phys Eng Express       Date:  2020-01-31

Review 9.  Can tumour response be assessed from a biopsy?

Authors:  K R Trott
Journal:  Br J Cancer Suppl       Date:  1980-04

Review 10.  New developments in radiation therapy for head and neck cancer: intensity-modulated radiation therapy and hypoxia targeting.

Authors:  Nancy Y Lee; Quynh-Thu Le
Journal:  Semin Oncol       Date:  2008-06       Impact factor: 4.929

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