Literature DB >> 36112419

NCOA4: More than a receptor for ferritinophagy.

Zheng Wang1, Hong Zhang1,2.   

Abstract

Liquid-liquid phase separation (LLPS) triages protein cargoes for autophagic degradation. In this issue, Ohshima et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203102) demonstrate that the autophagy receptor NCOA4 interacts with ferritin particles to form liquid-like condensates via LLPS. The NCOA4-ferritin condensates are delivered to lysosomes for degradation via either canonical macroautophagy or endosomal microautophagy to maintain intracellular iron homeostasis.
© 2022 Wang and Zhang.

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Year:  2022        PMID： 36112419      PMCID： PMC9485878          DOI： 10.1083/jcb.202209004

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   8.077


  10 in total

Review 1.  The role of Atg proteins in autophagosome formation.

Authors:  Noboru Mizushima; Tamotsu Yoshimori; Yoshinori Ohsumi
Journal:  Annu Rev Cell Dev Biol       Date:  2011-07-18       Impact factor: 13.827

2.  Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells.

Authors:  Takeshi Asano; Masaaki Komatsu; Yuko Yamaguchi-Iwai; Fuyuki Ishikawa; Noboru Mizushima; Kazuhiro Iwai
Journal:  Mol Cell Biol       Date:  2011-03-28       Impact factor: 4.272

3.  Wetting regulates autophagy of phase-separated compartments and the cytosol.

Authors:  Jaime Agudo-Canalejo; Sebastian W Schultz; Haruka Chino; Simona M Migliano; Chieko Saito; Ikuko Koyama-Honda; Harald Stenmark; Andreas Brech; Alexander I May; Noboru Mizushima; Roland L Knorr
Journal:  Nature       Date:  2021-01-20       Impact factor: 49.962

Review 4.  Microautophagy - distinct molecular mechanisms handle cargoes of many sizes.

Authors:  Sebastian Schuck
Journal:  J Cell Sci       Date:  2020-09-09       Impact factor: 5.285

5.  Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.

Authors:  Jonathan M Goodwin; William E Dowdle; Rowena DeJesus; Zuncai Wang; Philip Bergman; Marek Kobylarz; Alicia Lindeman; Ramnik J Xavier; Gregory McAllister; Beat Nyfeler; Gregory Hoffman; Leon O Murphy
Journal:  Cell Rep       Date:  2017-09-05       Impact factor: 9.423

6.  Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

Authors:  William E Dowdle; Beat Nyfeler; Jane Nagel; Robert A Elling; Shanming Liu; Ellen Triantafellow; Suchithra Menon; Zuncai Wang; Ayako Honda; Gwynn Pardee; John Cantwell; Catherine Luu; Ivan Cornella-Taracido; Edmund Harrington; Peter Fekkes; Hong Lei; Qing Fang; Mary Ellen Digan; Debra Burdick; Andrew F Powers; Stephen B Helliwell; Simon D'Aquin; Julie Bastien; Henry Wang; Dmitri Wiederschain; Jenny Kuerth; Philip Bergman; David Schwalb; Jason Thomas; Savuth Ugwonali; Fred Harbinski; John Tallarico; Christopher J Wilson; Vic E Myer; Jeffery A Porter; Dirksen E Bussiere; Peter M Finan; Mark A Labow; Xiaohong Mao; Lawrence G Hamann; Brendan D Manning; Reginald A Valdez; Thomas Nicholson; Markus Schirle; Mark S Knapp; Erin P Keaney; Leon O Murphy
Journal:  Nat Cell Biol       Date:  2014-10-19       Impact factor: 28.824

7.  Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.

Authors:  Joseph D Mancias; Laura Pontano Vaites; Sahar Nissim; Douglas E Biancur; Andrew J Kim; Xiaoxu Wang; Yu Liu; Wolfram Goessling; Alec C Kimmelman; J Wade Harper
Journal:  Elife       Date:  2015-10-05       Impact factor: 8.140

8.  Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice.

Authors:  Jizheng Chen; Yang Zhao; Chao Zhang; Hairong Chen; Jin Feng; Xiumei Chi; Yu Pan; Jun Du; Min Guo; Huang Cao; Honghe Chen; Zilong Wang; Rongjuan Pei; Qian Wang; Lei Pan; Junqi Niu; Xinwen Chen; Hong Tang
Journal:  Cell Res       Date:  2014-08-26       Impact factor: 25.617

9.  Liquid-liquid phase separation in autophagy.

Authors:  Nobuo N Noda; Zheng Wang; Hong Zhang
Journal:  J Cell Biol       Date:  2020-08-03       Impact factor: 10.539

10.  Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.

Authors:  Joseph D Mancias; Xiaoxu Wang; Steven P Gygi; J Wade Harper; Alec C Kimmelman
Journal:  Nature       Date:  2014-03-30       Impact factor: 49.962
  10 in total

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