Izaz Shaik1, Bhavyasri Gaddam2, Anjali Patel3, Rashmi Deshmukh4, Manasa Bhavana2, Mohana S M Sunku5, Anusha Minnikanti6. 1. Rutgers School of Dental Medicine, Newark, New Jersey, USA. 2. Albany, NY, USA. 3. K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University, Waghodiya, Vadodara, India. 4. Chief Sanitarian, Ector County Health Department, Texas, USA. 5. Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India. 6. MPH, Missouri State University, Springfield, MO, Senior Statistical Programmer with Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Abstract
Introduction: In this study, we investigated the success rate of growth factors for existing periapical lesions in failed endodontically treated teeth in an adult population by systematic review and meta-analysis. Materials and Methods: We conducted an online data search based on preferred reporting items for systematic reviews and meta analyses (PRISMA), from databases PUBMED, MEDLINE, and EMBASE, for the application of various types of growth factors in endodontically failed teeth with periapical lesions in adults. These included the "platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)," blood, etc. The data were meta-analyzed using MetaXL 5.3, and GRADE was used to assess the certainty. Results: We observed that success of 0.95 was achieved by the end of a year's follow-up with the application of growth factors for periodontal lesions. We also observed that the teeth responded to thermal tests, indicating regeneration; however, studies were with bias and lower sensitivity. Discussion: \ Similar to regeneration in immature teeth, growth factors also showed greater success in the treatment of periapical lesions in the failed endodontic teeth in adults. Copyright:
Introduction: In this study, we investigated the success rate of growth factors for existing periapical lesions in failed endodontically treated teeth in an adult population by systematic review and meta-analysis. Materials and Methods: We conducted an online data search based on preferred reporting items for systematic reviews and meta analyses (PRISMA), from databases PUBMED, MEDLINE, and EMBASE, for the application of various types of growth factors in endodontically failed teeth with periapical lesions in adults. These included the "platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)," blood, etc. The data were meta-analyzed using MetaXL 5.3, and GRADE was used to assess the certainty. Results: We observed that success of 0.95 was achieved by the end of a year's follow-up with the application of growth factors for periodontal lesions. We also observed that the teeth responded to thermal tests, indicating regeneration; however, studies were with bias and lower sensitivity. Discussion: \ Similar to regeneration in immature teeth, growth factors also showed greater success in the treatment of periapical lesions in the failed endodontic teeth in adults. Copyright:
Authors: George T-J Huang; Takayoshi Yamaza; Lonnie D Shea; Farida Djouad; Nastaran Z Kuhn; Rocky S Tuan; Songtao Shi Journal: Tissue Eng Part A Date: 2010-02 Impact factor: 3.845
Authors: C Brizuela; G Meza; D Urrejola; M A Quezada; G Concha; V Ramírez; I Angelopoulos; M I Cadiz; R Tapia-Limonchi; M Khoury Journal: J Dent Res Date: 2020-03-23 Impact factor: 6.116