Literature DB >> 36102178

The importance of phenoconversion when using the CYP2D6 genotype in clinical practice.

Emily J Cicali1,2, Kristin Wiisanen1,2.   

Abstract

Tweetable abstract Clinical phenoconversion needs to be incorporated when interpreting and applying CYP2D6 results in clinical care. This article describes how this can be performed either manually or by utilizing online tools and resources. #Phenoconversion #Pharmacogenomics.

Entities:  

Keywords:  CYP2D6; drug interaction; pharmacist; pharmacogenetics; pharmacogenomics; phenoconversion

Mesh：

Substances：

Year:  2022        PMID： 36102178      PMCID： PMC9490503          DOI： 10.2217/pgs-2022-0087

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.638


  22 in total

Review 1.  Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.

Authors:  Jacob T Brown; Jeffrey R Bishop; Katrin Sangkuhl; Erika L Nurmi; Daniel J Mueller; Jean C Dinh; Andrea Gaedigk; Teri E Klein; Kelly E Caudle; James T McCracken; Jose de Leon; J Steven Leeder
Journal:  Clin Pharmacol Ther       Date:  2019-04-13       Impact factor: 6.875

2.  The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.

Authors:  A Gaedigk; S D Simon; R E Pearce; L D Bradford; M J Kennedy; J S Leeder
Journal:  Clin Pharmacol Ther       Date:  2007-10-31       Impact factor: 6.875

Review 3.  Addressing phenoconversion: the Achilles' heel of personalized medicine.

Authors:  Rashmi R Shah; Robert L Smith
Journal:  Br J Clin Pharmacol       Date:  2015-02       Impact factor: 4.335

4.  Impact of CYP2D6 Functional Allelic Variations on Phenoconversion and Drug-Drug Interactions.

Authors:  Flavia Storelli; Alain Matthey; Sébastien Lenglet; Aurélien Thomas; Jules Desmeules; Youssef Daali
Journal:  Clin Pharmacol Ther       Date:  2017-11-06       Impact factor: 6.875

Review 5.  Complexities of CYP2D6 gene analysis and interpretation.

Authors:  Andrea Gaedigk
Journal:  Int Rev Psychiatry       Date:  2013-10

Review 6.  Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and the European Society for Pharmacogenomics and Personalized Therapy.

Authors:  Victoria M Pratt; Larisa H Cavallari; Andria L Del Tredici; Andrea Gaedigk; Houda Hachad; Yuan Ji; Lisa V Kalman; Reynold C Ly; Ann M Moyer; Stuart A Scott; R H N van Schaik; Michelle Whirl-Carrillo; Karen E Weck
Journal:  J Mol Diagn       Date:  2021-06-10       Impact factor: 5.341

Review 7.  How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial.

Authors:  Emily J Cicali; Amanda L Elchynski; Kelsey J Cook; John T Houder; Cameron D Thomas; D Max Smith; Amanda Elsey; Julie A Johnson; Larisa H Cavallari; Kristin Wiisanen
Journal:  Clin Pharmacol Ther       Date:  2021-07-28       Impact factor: 6.903

8.  Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.

Authors:  Larisa H Cavallari; Sara L Van Driest; Cynthia A Prows; Jeffrey R Bishop; Nita A Limdi; Victoria M Pratt; Laura B Ramsey; D Max Smith; Sony Tuteja; Benjamin Q Duong; J Kevin Hicks; James C Lee; Aniwaa Owusu Obeng; Amber L Beitelshees; Gillian C Bell; Kathryn Blake; Daniel J Crona; Lynn Dressler; Ryan A Gregg; Lindsay J Hines; Stuart A Scott; Richard C Shelton; Kristin Wiisanen Weitzel; Julie A Johnson; Josh F Peterson; Philip E Empey; Todd C Skaar
Journal:  Genet Med       Date:  2019-03-21       Impact factor: 8.822

9.  Sequence2Script: A Web-Based Tool for Translation of Pharmacogenetic Data Into Evidence-Based Prescribing Recommendations.

Authors:  Chad A Bousman; Patrick Wu; Katherine J Aitchison; Tony Cheng
Journal:  Front Pharmacol       Date:  2021-03-18       Impact factor: 5.810

Review 10.  Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.

Authors:  Kristine R Crews; Andrew A Monte; Rachel Huddart; Kelly E Caudle; Evan D Kharasch; Andrea Gaedigk; Henry M Dunnenberger; J Steven Leeder; John T Callaghan; Caroline Flora Samer; Teri E Klein; Cyrine E Haidar; Sara L Van Driest; Gualberto Ruano; Katrin Sangkuhl; Larisa H Cavallari; Daniel J Müller; Cynthia A Prows; Mohamed Nagy; Andrew A Somogyi; Todd C Skaar
Journal:  Clin Pharmacol Ther       Date:  2021-02-09       Impact factor: 6.903
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