Federica Turati1,2, Federica Concina3, Marta Rossi4, Federica Fiori5, Maria Parpinel5, Martina Taborelli6, Attilio Giacosa7, Anna Crispo8, Eleonora Pagan9, Valentina Rosato10, Eva Negri4,11, Carlo La Vecchia4. 1. Unit of Medical Statistics and Biometry, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. federica.turati@unimi.it. 2. Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. federica.turati@unimi.it. 3. Clinical Epidemiology and Public Health Research Unit, Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, Italy. 4. Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. 5. Department of Medicine, University of Udine, Udine, Italy. 6. Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy. 7. Department of Gastroenterology and Clinical Nutrition, Policlinico di Monza, Monza, Italy. 8. Epidemiology Unit, Istituto Tumori "Fondazione Pascale IRCCS", Naples, Italy. 9. Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy. 10. Unit of Medical Statistics and Biometry, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. 11. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Abstract
PURPOSE: To evaluate the association between the intake of specific fibers with prebiotic activity, namely inulin-type fructans (ITFs), fructooligosaccharides (FOSs) and galactooligosaccharides (GOSs), and colorectal cancer risk. METHODS: Within the PrebiotiCa study, we used data from a multicentric case-control study conducted in Italy and including 1953 incident, histologically confirmed, colorectal cancer patients and 4154 hospital controls. The amount of six prebiotic molecules [ITFs, nystose (FOS), kestose (FOS), 1F-β-fructofuranosylnystose (FOS), raffinose (GOS) and stachyose (GOS)] in a variety of foods was quantified via laboratory analyses. Subjects' prebiotic fiber intake was estimated by multiplying food frequency questionnaire intake by the prebiotic content of each food item. The odds ratios (OR) of colorectal cancer for quintiles of intakes were derived from logistic regression models including terms for major confounders and total energy intake. RESULTS: GOSs intake was inversely associated with colorectal cancer risk. The OR for the highest versus the lowest quintile of intake were 0.73 (95% confidence interval, CI 0.58-0.92) for raffinose and 0.64 (95% CI 0.53-0.77) for stachyose, with significant inverse trends across quintiles. No association was found with total ITFs and FOSs. The association with stachyose was stronger for colon (continuous OR = 0.74, 95% CI 0.66-0.83) than rectal cancer (OR = 0.89, 95% CI 0.79-1.02). CONCLUSION: Colorectal cancer risk was inversely associated with the intake of dietary GOSs, but not ITFs and FOSs.
PURPOSE: To evaluate the association between the intake of specific fibers with prebiotic activity, namely inulin-type fructans (ITFs), fructooligosaccharides (FOSs) and galactooligosaccharides (GOSs), and colorectal cancer risk. METHODS: Within the PrebiotiCa study, we used data from a multicentric case-control study conducted in Italy and including 1953 incident, histologically confirmed, colorectal cancer patients and 4154 hospital controls. The amount of six prebiotic molecules [ITFs, nystose (FOS), kestose (FOS), 1F-β-fructofuranosylnystose (FOS), raffinose (GOS) and stachyose (GOS)] in a variety of foods was quantified via laboratory analyses. Subjects' prebiotic fiber intake was estimated by multiplying food frequency questionnaire intake by the prebiotic content of each food item. The odds ratios (OR) of colorectal cancer for quintiles of intakes were derived from logistic regression models including terms for major confounders and total energy intake. RESULTS: GOSs intake was inversely associated with colorectal cancer risk. The OR for the highest versus the lowest quintile of intake were 0.73 (95% confidence interval, CI 0.58-0.92) for raffinose and 0.64 (95% CI 0.53-0.77) for stachyose, with significant inverse trends across quintiles. No association was found with total ITFs and FOSs. The association with stachyose was stronger for colon (continuous OR = 0.74, 95% CI 0.66-0.83) than rectal cancer (OR = 0.89, 95% CI 0.79-1.02). CONCLUSION: Colorectal cancer risk was inversely associated with the intake of dietary GOSs, but not ITFs and FOSs.
Authors: Heinz Freisling; Melina Arnold; Isabelle Soerjomataram; Mark George O'Doherty; José Manuel Ordóñez-Mena; Christina Bamia; Ellen Kampman; Michael Leitzmann; Isabelle Romieu; Frank Kee; Konstantinos Tsilidis; Anne Tjønneland; Antonia Trichopoulou; Paolo Boffetta; Vassiliki Benetou; H B As Bueno-de-Mesquita; José María Huerta; Hermann Brenner; Tom Wilsgaard; Mazda Jenab Journal: Br J Cancer Date: 2017-04-25 Impact factor: 7.640
Authors: Lauren G Aoude; Antonia L Pritchard; Carla Daniela Robles-Espinoza; Karin Wadt; Mark Harland; Jiyeon Choi; Michael Gartside; Víctor Quesada; Peter Johansson; Jane M Palmer; Andrew J Ramsay; Xijun Zhang; Kristine Jones; Judith Symmons; Elizabeth A Holland; Helen Schmid; Vanessa Bonazzi; Susan Woods; Ken Dutton-Regester; Mitchell S Stark; Helen Snowden; Remco van Doorn; Grant W Montgomery; Nicholas G Martin; Thomas M Keane; Carlos López-Otín; Anne-Marie Gerdes; Håkan Olsson; Christian Ingvar; Ake Borg; Nelleke A Gruis; Jeffrey M Trent; Göran Jönsson; D Timothy Bishop; Graham J Mann; Julia A Newton-Bishop; Kevin M Brown; David J Adams; Nicholas K Hayward Journal: J Natl Cancer Inst Date: 2014-12-13 Impact factor: 13.506