Literature DB >> 3608565

Heterogeneous expression of melanoma-associated antigens in uveal melanomas.

J P van der Pol, M J Jager, D de Wolff-Rouendaal, P J Ringens, C Vennegoor, D J Ruiter.   

Abstract

Twenty-five uveal melanomas were stained with seven monoclonal antibodies (MoAbs) recognizing different antigens on cutaneous melanomas. A two step immuno-peroxidase procedure was used. Phenotypic heterogeneity was observed for four MoAbs (M.2.2.4, AMF-7, 225.28S, PAL-M1) while two MoAbs (NKI-beteb, CL203.4) reacted strongly with most (85%) uveal melanomas, and one MoAb (R-24) showed very low reactivity. Despite heterogeneity, co-expression of some antigens was observed. Expression of the antigen recognized by MoAb M.2.2.4. was significantly lowered by pre-enucleation irradiation while the other antigens remained unchanged. Expression of antigens on uveal melanomas differed markedly from primary cutaneous melanomas. The clinical relevance of these findings awaits further study.

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Year:  1987        PMID： 3608565     DOI： 10.3109/02713688709034842

Source DB:  PubMed          Journal:  Curr Eye Res        ISSN： 0271-3683            Impact factor:   2.424


  10 in total

1.  Melanocyte lineage-specific antigens recognized by monoclonal antibodies NKI-beteb, HMB-50, and HMB-45 are encoded by a single cDNA.

Authors:  G J Adema; A J de Boer; R van 't Hullenaar; M Denijn; D J Ruiter; A M Vogel; C G Figdor
Journal:  Am J Pathol       Date:  1993-12       Impact factor: 4.307

2.  Immunoscintigraphy for ocular melanoma: a reliable diagnostic technique?

Authors:  K U Loeffler; P Bräutigam; J C Simon; S R Althauser; C Wuttig; H Witschel
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-02       Impact factor: 3.117

3.  A monoclonal antibody specific for cells of the melanocyte lineage.

Authors:  C Vennegoor; P Hageman; H Van Nouhuijs; D J Ruiter; J Calafat; P J Ringens; P Rümke
Journal:  Am J Pathol       Date:  1988-01       Impact factor: 4.307

4.  Radioimmunoscintigraphy and immunohistochemistry with melanoma-associated monoclonal antibodies in choroidal melanoma: a comparison of the clinical and immunohistochemical results.

Authors:  D F Schaling; J P van der Pol; M J Jager; M J van Kroonenburgh; J A Oosterhuis; D J Ruiter
Journal:  Br J Ophthalmol       Date:  1990-09       Impact factor: 4.638

5.  Radioimmunoscintigraphy with melanoma-associated monoclonal antibody fragments in choroidal melanoma.

Authors:  D F Schaling; M J van Kroonenburgh; R A Borsje; J A Camps; H M Kakebeeke-Kemme; J A Oosterhuis; E K Pauwels
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1989       Impact factor: 3.117

6.  Monoclonal antibodies in detection of choroidal melanoma.

Authors:  P J Ringens; R van Haperen; C Vennegoor; P T de Jong; S G van Duinen; D J Ruiter; A W van der Kamp
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1989       Impact factor: 3.117

7.  Possibilities and limitations of radioimmunoscintigraphy and conventional diagnostic modalities in choroidal melanoma.

Authors:  D F Schaling; J A Oosterhuis; M J Jager; H Kakebeeke-Kemme; E K Pauwels
Journal:  Br J Ophthalmol       Date:  1994-04       Impact factor: 4.638

8.  Immunoimaging of choroidal melanoma: assessment of its diagnostic accuracy and limitations in 101 cases.

Authors:  J Scheidler; G Leinsinger; C M Kirsch; O F Scheiffarth; F H Stefani; K G Riedel
Journal:  Br J Ophthalmol       Date:  1992-08       Impact factor: 4.638

9.  Immunoscintigraphy with three step monoclonal pretargeting technique in diagnosis of uveal melanoma: preliminary results.

Authors:  G Modorati; R Brancato; G Paganelli; P Magnani; R Pavoni; F Fazio
Journal:  Br J Ophthalmol       Date:  1994-01       Impact factor: 4.638

10.  High expression of immunotherapy candidate proteins gp100, MART-1, tyrosinase and TRP-1 in uveal melanoma.

Authors:  T J de Vries; D Trancikova; D J Ruiter; G N van Muijen
Journal:  Br J Cancer       Date:  1998-11       Impact factor: 7.640
  10 in total

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