Literature DB >> 36085064

Impact of N6-methyladenosine (m6A) modification on immunity.

Raghda A Elsabbagh1, Mona Rady2,3, Carsten Watzl4, Khaled Abou-Aisha5, Mohamed Z Gad1.   

Abstract

N6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m6A modification has been implicated in various human diseases. Thus, m6A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m6A in regulating immune cell functions and immune responses. Video abstract.
© 2022. The Author(s).

Entities:  

Keywords:  Adaptive; Immunity; Innate; N6-methyl-adenosine; m6A erasers; m6A readers; m6A writers

Mesh：

Substances：

Year:  2022        PMID： 36085064      PMCID： PMC9461097          DOI： 10.1186/s12964-022-00939-8

Source DB:  PubMed          Journal:  Cell Commun Signal        ISSN： 1478-811X            Impact factor:   7.525


  90 in total

1.  Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.

Authors:  Katalin Karikó; Michael Buckstein; Houping Ni; Drew Weissman
Journal:  Immunity       Date:  2005-08       Impact factor: 31.745

Review 2.  Regulation of Viral Infection by the RNA Modification N6-Methyladenosine.

Authors:  Graham D Williams; Nandan S Gokhale; Stacy M Horner
Journal:  Annu Rev Virol       Date:  2019-07-05       Impact factor: 10.431

3.  Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.

Authors:  Bastian Linder; Anya V Grozhik; Anthony O Olarerin-George; Cem Meydan; Christopher E Mason; Samie R Jaffrey
Journal:  Nat Methods       Date:  2015-06-29       Impact factor: 28.547

4.  N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection.

Authors:  Charles R Hesser; John Karijolich; Dan Dominissini; Chuan He; Britt A Glaunsinger
Journal:  PLoS Pathog       Date:  2018-04-16       Impact factor: 6.823

Review 5.  Structural Insights into N6-methyladenosine (m6A) Modification in the Transcriptome.

Authors:  Jinbo Huang; Ping Yin
Journal:  Genomics Proteomics Bioinformatics       Date:  2018-04-27       Impact factor: 7.691

6.  m6A-Dependent RNA Dynamics in T Cell Differentiation.

Authors:  Mattia Furlan; Eugenia Galeota; Stefano de Pretis; Michele Caselle; Mattia Pelizzola
Journal:  Genes (Basel)       Date:  2019-01-08       Impact factor: 4.096

7.  The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.

Authors:  Shoubao Ma; Jiazhuo Yan; Tasha Barr; Jianying Zhang; Zhenhua Chen; Li-Shu Wang; Joseph C Sun; Jianjun Chen; Michael A Caligiuri; Jianhua Yu
Journal:  J Exp Med       Date:  2021-06-23       Impact factor: 17.579

8.  Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

Authors:  Angelo Scuteri; Serena Sanna; Wei-Min Chen; Manuela Uda; Giuseppe Albai; James Strait; Samer Najjar; Ramaiah Nagaraja; Marco Orrú; Gianluca Usala; Mariano Dei; Sandra Lai; Andrea Maschio; Fabio Busonero; Antonella Mulas; Georg B Ehret; Ashley A Fink; Alan B Weder; Richard S Cooper; Pilar Galan; Aravinda Chakravarti; David Schlessinger; Antonio Cao; Edward Lakatta; Gonçalo R Abecasis
Journal:  PLoS Genet       Date:  2007-07       Impact factor: 5.917

9.  N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.

Authors:  Nagaraja Tirumuru; Boxuan Simen Zhao; Wuxun Lu; Zhike Lu; Chuan He; Li Wu
Journal:  Elife       Date:  2016-07-02       Impact factor: 8.140

10.  Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.

Authors:  Huilin Huang; Hengyou Weng; Wenju Sun; Xi Qin; Hailing Shi; Huizhe Wu; Boxuan Simen Zhao; Ana Mesquita; Chang Liu; Celvie L Yuan; Yueh-Chiang Hu; Stefan Hüttelmaier; Jennifer R Skibbe; Rui Su; Xiaolan Deng; Lei Dong; Miao Sun; Chenying Li; Sigrid Nachtergaele; Yungui Wang; Chao Hu; Kyle Ferchen; Kenneth D Greis; Xi Jiang; Minjie Wei; Lianghu Qu; Jun-Lin Guan; Chuan He; Jianhua Yang; Jianjun Chen
Journal:  Nat Cell Biol       Date:  2018-02-23       Impact factor: 28.824
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