| Literature DB >> 36083540 |
Abstract
On-DNA reductive amination (on-DNA aldehyde with amine building blocks) and alkylation (on-DNA amine with aldehyde building blocks) are robust ways to form C-N bond. The large sets of commercially available aldehyde and amine building blocks make reductive amination and alkylation widely used in DEL synthesis.Entities:
Keywords: DNA-encoded library (DEL); Reductive alkylation; Reductive amination
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Year: 2022 PMID： 36083540 DOI： 10.1007/978-1-0716-2545-3_5
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745