Literature DB >> 21504168

The medicinal chemist's toolbox: an analysis of reactions used in the pursuit of drug candidates.

Stephen D Roughley1, Allan M Jordan.   

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Year:  2011        PMID： 21504168     DOI： 10.1021/jm200187y

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  247 in total

1.  π-Facial Selectivities in Hydride Reductions of Hindered Endocyclic Iminium Ions.

Authors:  Shuming Chen; Amy Y Chan; Morgan M Walker; Jonathan A Ellman; K N Houk
Journal:  J Org Chem       Date:  2018-12-19       Impact factor: 4.354

Review 2.  Finding the sweet spot: the role of nature and nurture in medicinal chemistry.

Authors:  Michael M Hann; György M Keserü
Journal:  Nat Rev Drug Discov       Date:  2012-04-30       Impact factor: 84.694

Review 3.  The influence of the 'organizational factor' on compound quality in drug discovery.

Authors:  Paul D Leeson; Stephen A St-Gallay
Journal:  Nat Rev Drug Discov       Date:  2011-09-30       Impact factor: 84.694

4.  Characterization of Iron-Imido Species Relevant for N-Group Transfer Chemistry.

Authors:  Diana A Iovan; Theodore A Betley
Journal:  J Am Chem Soc       Date:  2016-02-04       Impact factor: 15.419

5.  A Merged Aldol Condensation, Alkene Isomerization, Cycloaddition/Cycloreversion Sequence Employing Oxazinone Intermediates for the Synthesis of Substituted Pyridines.

Authors:  Jill B Williamson; Emily R Smith; Jonathan R Scheerer
Journal:  Synlett       Date:  2017-02-23       Impact factor: 2.454

6.  Treatment of Halogen Bonding in the OPLS-AA Force Field; Application to Potent Anti-HIV Agents.

Authors:  William L Jorgensen; Patric Schyman
Journal:  J Chem Theory Comput       Date:  2012-04-03       Impact factor: 6.006

7.  Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines.

Authors:  Alexia N Kim; Aurapat Ngamnithiporn; Eric R Welin; Martin T Daiger; Christian U Grünanger; Michael D Bartberger; Scott C Virgil; Brian M Stoltz
Journal:  ACS Catal       Date:  2020-02-10       Impact factor: 13.084

8.  Elucidating the Role of the Boronic Esters in the Suzuki-Miyaura Reaction: Structural, Kinetic, and Computational Investigations.

Authors:  Andy A Thomas; Andrew F Zahrt; Connor P Delaney; Scott E Denmark
Journal:  J Am Chem Soc       Date:  2018-03-15       Impact factor: 15.419

9.  Rapid Construction of (-)-Paroxetine and (-)-Femoxetine via N-Heterocyclic Carbene Catalyzed Homoenolate Addition to Nitroalkenes.

Authors:  Nicholas A White; Kerem E Ozboya; Darrin M Flanigan; Tomislav Rovis
Journal:  Asian J Org Chem       Date:  2014-04       Impact factor: 3.319

10.  Iron-Catalyzed Oxyfunctionalization of Aliphatic Amines at Remote Benzylic C-H Sites.

Authors:  Curren T Mbofana; Eugene Chong; James Lawniczak; Melanie S Sanford
Journal:  Org Lett       Date:  2016-08-16       Impact factor: 6.005
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