BACKGROUND: Blood pressure variability (BPV) is of prognostic value for fatal and non-fatal cardiovascular outcomes. OBJECTIVE: This study aimed to evaluate the association between within-visit BPV and cardiovascular risk among participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). METHODS: The present cross-sectional study was carried out using baseline data (2008-2010) of 14,357 ELSA-Brasil participants with no prior history of cardiovascular disease. Within-visit BPV was quantified by the coefficient of variation of three standardized systolic blood pressure (SBP) measurements using an oscillometer. Anthropometric measurements and laboratory tests were also performed. Cardiovascular risk was assessed using the atherosclerotic cardiovascular disease risk estimator (ASCVD) and multivariate logistic regression analysis was employed with a significance level of 5%. RESULTS: Significantly higher cardiovascular risk was determined by increased BPV for both sexes. A significantly higher prevalence of high risk was found in men than women across all quartiles, with the highest difference observed in the fourth quartile of variability (48.3% vs. 17.1%). Comparisons among quartiles in each sex revealed a significantly higher cardiovascular risk for men in the third (OR=1.20; 95%CI: 1.02 - 1.40) and fourth quartiles (OR=1.46; 95%CI: 1.25 -1.71), and for women in the fourth quartile (OR=1.27; 95%CI: 1.03 - 1.57). CONCLUSION: Analysis of baseline data of the ELSA-Brasil participants revealed that blood pressure variability was associated with increased cardiovascular risk, especially in men.
BACKGROUND: Blood pressure variability (BPV) is of prognostic value for fatal and non-fatal cardiovascular outcomes. OBJECTIVE: This study aimed to evaluate the association between within-visit BPV and cardiovascular risk among participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). METHODS: The present cross-sectional study was carried out using baseline data (2008-2010) of 14,357 ELSA-Brasil participants with no prior history of cardiovascular disease. Within-visit BPV was quantified by the coefficient of variation of three standardized systolic blood pressure (SBP) measurements using an oscillometer. Anthropometric measurements and laboratory tests were also performed. Cardiovascular risk was assessed using the atherosclerotic cardiovascular disease risk estimator (ASCVD) and multivariate logistic regression analysis was employed with a significance level of 5%. RESULTS: Significantly higher cardiovascular risk was determined by increased BPV for both sexes. A significantly higher prevalence of high risk was found in men than women across all quartiles, with the highest difference observed in the fourth quartile of variability (48.3% vs. 17.1%). Comparisons among quartiles in each sex revealed a significantly higher cardiovascular risk for men in the third (OR=1.20; 95%CI: 1.02 - 1.40) and fourth quartiles (OR=1.46; 95%CI: 1.25 -1.71), and for women in the fourth quartile (OR=1.27; 95%CI: 1.03 - 1.57). CONCLUSION: Analysis of baseline data of the ELSA-Brasil participants revealed that blood pressure variability was associated with increased cardiovascular risk, especially in men.
Authors: Estela M L Aquino; Sandhi Maria Barreto; Isabela M Bensenor; Marilia S Carvalho; Dóra Chor; Bruce B Duncan; Paulo A Lotufo; José Geraldo Mill; Maria Del Carmen Molina; Eduardo L A Mota; Valéria Maria Azeredo Passos; Maria Inês Schmidt; Moyses Szklo Journal: Am J Epidemiol Date: 2012-01-10 Impact factor: 4.897
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Authors: Dóra Chor; Antonio Luiz Pinho Ribeiro; Marilia Sá Carvalho; Bruce Bartholow Duncan; Paulo Andrade Lotufo; Aline Araújo Nobre; Estela Mota Lima Leão de Aquino; Maria Inês Schmidt; Rosane Härter Griep; Maria Del Carmen Bisi Molina; Sandhi Maria Barreto; Valéria Maria de Azeredo Passos; Isabela Judith Martins Benseñor; Sheila Maria Alvim Matos; José Geraldo Mill Journal: PLoS One Date: 2015-06-23 Impact factor: 3.240