| Literature DB >> 36065136 |
Jonas F Ludvigsson1,2,3.
Abstract
AIM: Sweden initially chose a different disease prevention and control path during the pandemic than many other European countries. In June 2020, the Swedish Government established a National Commission to examine the management of COVID-19 in Sweden. This paper summarises, and discusses, its findings.Entities:
Keywords: COVID-19; Government inquiry; Pandemic; Schools; Strategy; Sweden
Year: 2022 PMID: 36065136 PMCID: PMC9538368 DOI: 10.1111/apa.16535
Source DB: PubMed Journal: Acta Paediatr ISSN: 0803-5253 Impact factor: 4.056
FIGURE 1Daily number of new Swedish COVID‐19 cases, cases in intensive care units (ICUs) and deaths after COVID‐19 (according to the Swedish Public Health Agency). In February 2022, public testing for the SARS‐COV‐2 virus, which causes COVID‐19, was no longer encouraged and data on the number of new cases are uncertain after this point. ICU cases and deaths should however still be reliable after February 2022. The number of deaths is discussed in more detail in the main text. The number of cases during the first wave was greatly underestimated because of a lack of testing in spring 2020
Characteristics of people receiving social care in Sweden
| Any social care receiver |
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| During a 14‐day period, an average of 16 different care providers (people) will visit a home support beneficiary with ≥2 visits per day | |
| Long‐term residential care facilities for older people |
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disoriented (64%) urinary incontinence (56%) severe/very severe cognitive problems (usually dementia)(48%) use of a wheelchair (37%) faecal incontinence (32%) |
The four most common forms of social care in order of frequency were security alarm, home support, residential care facility for older people and food deliveries.
In Swedish ‘SÄBO’.
Commission's recommendations for elderly care
| Staffing levels | The status and appeal of elderly care work must increase. Sweden must clarify what an appropriate staffing level is for residential care and caring for patients with dementia |
| Employers must facilitate true leadership in residential care and ensure that middle managers are not responsible for excessively large workforces | |
| Employment security and employees paid by the hour | Employment security should increase |
| The proportion of the workforce made up of employees paid by the hour should decrease | |
| Contact between care providers and people receiving care | People receiving care should see the same healthcare staff over time |
| All residential care should have access to a nurse 24/7 to guarantee high medical expertise when residents need intravenous hydration and oxygen and when staff with lower medical competence need supervision and guidance | |
| Competence | The (Swedish) language skills of healthcare staff involved in caring for older people |
Mostly based on the first wave of the pandemic (spring 2020).
Low staffing levels caused problems such as difficulties to follow COVID‐19 hygiene recommendations because of high workload. Low staffing levels also hindered staff from informing themselves about the pandemic and relevant measures, such as time to read relevant emails.
In the three largest cities in Sweden (Stockholm. Gothenburg, Malmö), 56% of the staff in elderly care did not have Swedish as their primary language. In the rest of the country, the corresponding percentage was 19%.
FIGURE 2Cumulative mortality per million inhabitants following COVID‐19 in selected European countries up to 25 February 2022. Data in the figure are based on Arnarson (Sci Rep. 2021)
FIGURE 3COVID‐19 government response (Stringency Index)* in Sweden and selected countries, according to the Blavatnik School of Government, University of Oxford, 1 January 2020 until 25 February 2022. Swe, Sweden (red line). DNK, Denmark. Fin, Finland. Nor, Norway. Bel, Belgium. GBR, Great Britain. USA, United States. A high index equals a more stringent lockdown (with the highest numbers for Great Britain (yellow) in early 2021. *The Stringency Index is a composite measure based on nine response indicators including school closures, workplace closures and travel bans
Postponed and delayed health care in 2020
| Child health |
Obesity probably increased in children aged 3–5 years of age and this increase could have been higher in groups with low socioeconomic status. In a report from the Swedish opinion poll institute in May 2020, a quarter of children aged 8–18 years reported having exercised less in 2020. The proportion was even higher in children aged 16–18 years, at almost a half. Childhood vaccination rates were not affected and remained high throughout the pandemic |
| Prescriptions/dispensed medication |
Increased dispensing of antihypertensives Decreased dispensing of antibiotics in spring 2020, mostly in children |
| Inpatient episodes decreased (hospital‐based admissions and visits) |
Cardiovascular disease (−9%) Myocardial infarction (−10%) Respiratory disease (−31%) Cancer (−9%) Musculoskeletal disease (−18%) Number of rheumatoid arthritis visits to departments of medicine/rheumatology (−20%) Gastrointestinal disease (−5%) Psychiatric care (−4%) Neurological disease (−8%) Visits for certain immune‐mediated diseases decreased, including eye disease examinations for patients with diabetes |
| Visits to health care |
20% of all adults reported 39% of all adults said they had |
| Cancer screening |
Breast cancer screening was paused in certain regions Cervical cancer screening (−5%) |
| Surgery |
Planned surgery (−11%) Emergency surgery (−3%) |
| Other | Follow‐ups for certain major cancers were affected |
Note: Data from the Commission reports and personal communication with Professor Anders Ekbom (Karolinska Institutet, 31 July 2022).
During the first wave, some thought that these drugs would protect people against COVID‐19.
Selected health and healthcare recommendations from the Swedish COVID‐19 Commission
| A precautionary principle |
While crisis management in Sweden should be based on principles of responsibility, similarity and subsidiarity, a The Commission defines the precautionary principle as ‘ |
| Pandemic preparedness | Sweden needs to strengthen its pandemic preparedness, at governmental, regional and municipal levels, including mental and legal preparedness and material and organisational preparedness |
| Government leadership | In a future crisis, the Government, rather than government agencies, should assume leadership of all aspects of crisis management. Furthermore, the Government should not rely solely on one agency for advice. A national crisis management group should be established that directly reports to the Government |
| Documentation | Crisis management decisions must be better documented |
| International collaboration | Sweden needs to improve international collaborations related to communicable diseases and build up emergency stockpiles, both nationally and within the European Union (EU). The EU collaboration to purchase vaccines was regarded as successful |
| Public communication |
Swedish authorities must improve infectious disease prevention and control communications to all parts of society and make sure they are clear. Statements such as ‘Do not participate in large gatherings such as weddings’ or ‘think about whether you could save a trip until next Easter’ should have been clarified and sometimes replaced by clearer and more concise language. Communication should have been more inclusive |
| Communicable Disease Act | The Communicable Disease Act needs to focus more on health at the population level |
| Administrative reforms | Sweden needs to reform its administrative model, decrease the number of actors in health care and municipal care and increase regional, national and international cooperation |
| Care for older people | The staffing and quality of elderly care must increase |
| Information technology systems | The country needs more efficient information technology systems, including follow‐up testing and analysis |
| Need for data for improved decision‐making | Data are currently missing on primary care, residential care for older people, social care, municipal health and short‐term sick leave |
Not all pandemics are due to influenza. Before COVID‐19, Sweden's pandemic preparedness targeted a relatively short influenza pandemic in which older adults were already expected to have some immunity through earlier influenza exposure. There was also an expectation that effective vaccines would be available within 4–5 months in the event of an influenza pandemic.
After the H1N1 influenza pandemic, young people and people who spoke other languages than Swedish as their native language were difficult to reach with recommendations and advice.
Primary care is often responsible for patients with chronic diseases such as type 2 diabetes and psychiatric disorders. Primary care data would also have been useful on the long‐term, follow‐up consequences of the pandemic on mental health. Data on short‐term sick leave would have helped monitor viral transmission in society and the pandemic's impact on society.
Management of COVID‐19 in adults at one regional hospital in Sweden during the third wave in spring 2021
| Common indications for hospital admission in patients with COVID‐19 |
Oxygen saturation <93% Frequency of breathing >24 Dyspnoea while resting/or unable to perform low‐intensity physical exercise Underlying (severe) chronic disease: cardiovascular, kidney, etc |
| Underlying comorbidity and implications for care |
Diabetes: inhibit oral antidiabetics (especially metformin) and replace them with insulin Transient diabetes may occur secondary to Dexamethasone treatment Chronic obstructive pulmonary disease: target saturation is 88–92% (slightly lower than for other patients) Immunocompromised: avoid tocilizumab treatment Weight: for obese patients (>90 kg) increase dalteparin dosage (consider decreasing dosage in patients <50 kg) History of thromboembolism: increase dalteparin dosage Cancer: increase dalteparin dosage Pregnant patients: discuss care with obstetrician |
| Laboratory data and their implications for care |
Neutropenia: avoid tocilizumab Thrombocyte count <30x10(9)/L: avoid dalteparin C‐reactive protein (CRP) >75 mg/L: give tocilizumab CRP >100 mg/L: Give dexamethasone D‐dimer >3 mg/L or fibrinogen >8 g/L: consider increasing dalteparin Alanine transaminase (ALAT) >5 microcat/L: avoid tocilizumab and remdesivir |
| Thorax CT scan | Perform in all patients needing high‐flow/airvo oxygen or mechanical ventilation. Look for pulmonary embolism, ground‐glass appearance (early disease) or consolidation (late disease) |
| Prone position | Preferred sleep position for patients with severe COVID‐19. It may cause pain in the neck (treat with paracetamol) |
| Dexamethasone use |
Indications: inflammation (CRP >100 mg/L or ferritin >1000 microg/L), fever, substantial oxygen need or patient is very sick on Day 7 after symptom onset (i.e. prolonged disease) 6 mg per day Add omeprazole for gastric protection Regular check‐ups of plasma glucose (to detect incident diabetes) Treatment duration: 6–10 days |
| Tocilizumab |
Indications: inflammation (CRP >75 mg), substantial lung involvement Contraindications: immunocompromised (especially if the patient is on rituximab), neutropenia, pregnancy, platelet/thrombocyte count (TPK) <50x10(9)/L, ALAT >5 microcat/L Will suppress CRP. If there is suspicion of bacterial infection, check procalcitonin level |
| Remdesivir |
Oxygen need plus ≤7 days since symptom onset (remdesivir will mitigate virus replication, which is high in Only prescribe after discussion with an infectious disease specialist Treatment duration: 5 days |
| Thromboprophylaxis |
Standard dosage: dalteparin 5000E Increase dosage: >90 kg, intensive care, D‐dimer >3 mg/L, fibrinogen>8 g/L and history of cancer or thromboembolism Be cautious: pregnancy, simultaneous Non‐steroidal anti‐inflammatory drugs (NSAIDs) No dalteparin: Glomerular filtration rate (GFR) <30 mL/min/1.73m(2) or TPK <30x10(9)/L At hospital discharge: apixaban 2.5 mg*2 for 2 weeks (4 weeks if severe COVID‐19). Consider higher dosage if the patient had apixaban already before COVID‐19 disease |
| Bacterial infections |
In COVID‐19, CRP is often 100 or even 200 mg/L, even in the absence of bacterial infections Use procalcitonin to detect bacterial infection In tocilizumab users: always use procalcitonin (do not trust CRP) to evaluate bacterial infections If suspected bacterial infection: start cefotaxime 2g*3 and avoid tocilizumab |
| Other COVID‐19‐related health measures |
Sleeping difficulties: zopiclone 5 mg. Pain from prolonged bed confinement: paracetamol High energy need. Nutritional support is often needed. Involve a dietician |
| Measures at discharge |
Cease dalteparin and start apixaban. Cease dexamethasone Follow‐up with a nurse in 2 weeks Follow‐up with a physician in 3 months if intensive care, pulmonary emboli, mechanical ventilation or ≥5 days of high‐flow oxygen |
| Regarded as non‐contagious | Always required before declared non‐contagious: 2 days with normal temperature and general improvement, plus:
In patients not hospitalised: 7 days since symptom onset Patient with oxygen treatment at hospital: 14 days since symptom onset Patient in intensive care unit/immunocompromised |
Note: Based on the personal experience of Jonas F Ludvigsson and local guidelines. The table refers to Örebro University Hospital principally serving the Örebro region.
The cut‐off for admission varied. In times of severe pressure in the wards, only COVID‐19 patients with a breathing frequency exceeding 35 were admitted to hospital.
Patients with cancer, neutropenia or certain immunosuppressive medications.