Literature DB >> 36063301

Stem Cell Exosomes Improve Survival of Neural Stem Cells after Radiation Exposure.

M G Ratushnyak1, Yu P Semochkina2, E V Yastremsky2, R A Kamyshinsky2.   

Abstract

The death of neural stem cells in the hippocampus during radiation therapy of brain tumors leads to neurogenesis impairment and the development of cognitive dysfunctions at delayed terms after irradiation. Exosomes secreted by stem cells can provide a protective effect on neural stem cells. We isolated and characterized exosomes from the medium conditioned by neural stem cells and mesenchymal stem cells from mouse adipose tissue and studied their efficiency in protecting irradiated neural stem cells. According to dynamic light scattering data, the exosome size varied from 44 to 68 nm for neural stem cells, and from 80 to 130 nm for mesenchymal stem cells. All exosomes carried markers CD9, CD63, and TSG101. The survival rate and clonogenic activity of neural stem cells irradiated in a dose of 1 Gy was found to increase after culturing in the presence of stem cell exosome preparations.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  cell therapy; exosomes; gamma radiation; mesenchymal stem cells; neural stem cells

Mesh：

Year:  2022        PMID： 36063301     DOI： 10.1007/s10517-022-05587-z

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.737


  29 in total

1.  Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment.

Authors:  Munjal M Acharya; Vahan Martirosian; Lori-Ann Christie; Lara Riparip; Jan Strnadel; Vipan K Parihar; Charles L Limoli
Journal:  Stem Cells Transl Med       Date:  2014-11-12       Impact factor: 6.940

2.  Murine adipose-derived mesenchymal stromal cell vesicles: in vitro clues for neuroprotective and neuroregenerative approaches.

Authors:  Alessia Farinazzo; Ermanna Turano; Silvia Marconi; Edoardo Bistaffa; Elena Bazzoli; Bruno Bonetti
Journal:  Cytotherapy       Date:  2015-03-03       Impact factor: 5.414

Review 3.  Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.

Authors:  Marina Colombo; Graça Raposo; Clotilde Théry
Journal:  Annu Rev Cell Dev Biol       Date:  2014-08-21       Impact factor: 13.827

4.  Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.

Authors:  Mathew Blurton-Jones; Masashi Kitazawa; Hilda Martinez-Coria; Nicholas A Castello; Franz-Josef Müller; Jeanne F Loring; Tritia R Yamasaki; Wayne W Poon; Kim N Green; Frank M LaFerla
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-24       Impact factor: 11.205

5.  Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis.

Authors:  Roberta Bonafede; Ilaria Scambi; Daniele Peroni; Valentina Potrich; Federico Boschi; Donatella Benati; Bruno Bonetti; Raffaella Mariotti
Journal:  Exp Cell Res       Date:  2015-12-18       Impact factor: 3.905

6.  Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain.

Authors:  Janet E Baulch; Munjal M Acharya; Barrett D Allen; Ning Ru; Nicole N Chmielewski; Vahan Martirosian; Erich Giedzinski; Amber Syage; Audrey L Park; Sarah N Benke; Vipan K Parihar; Charles L Limoli
Journal:  Proc Natl Acad Sci U S A       Date:  2016-04-04       Impact factor: 11.205

Review 7.  Stem-Cell Therapy as a Potential Strategy for Radiation-Induced Brain Injury.

Authors:  Chengyan Chu; Yue Gao; Xiaoyan Lan; Jianwen Lin; Aline M Thomas; Shen Li
Journal:  Stem Cell Rev Rep       Date:  2020-08       Impact factor: 5.739

8.  Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury.

Authors:  Daniel L Haus; Luci López-Velázquez; Eric M Gold; Kelly M Cunningham; Harvey Perez; Aileen J Anderson; Brian J Cummings
Journal:  Exp Neurol       Date:  2016-04-11       Impact factor: 5.330

Review 9.  Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges.

Authors:  Dinh Ha; Ningning Yang; Venkatareddy Nadithe
Journal:  Acta Pharm Sin B       Date:  2016-03-08       Impact factor: 11.413

10.  Radiation-induced brain injury: A review.

Authors:  Dana Greene-Schloesser; Mike E Robbins; Ann M Peiffer; Edward G Shaw; Kenneth T Wheeler; Michael D Chan
Journal:  Front Oncol       Date:  2012-07-19       Impact factor: 6.244
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.