Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans.

Literature DB >> 3606068

Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans.

P Chanson, V Joly, A Contrepois, J J Garaud, J Bauchet, J Mohler, P C Nguyen, C Carbon.

Abstract

We studied the effect of the control of the hypothyroid state in humans on the pharmacokinetic parameters of cefazolin and gentamicin after a single intravenous injection. These two antibiotics were chosen because of their different patterns of binding to serum albumin (0% for gentamicin and 82% for cefazolin). In hypothyroidism, the behavior of cefazolin only was altered, with a decrease in the total body clearance, possibly due to reduced urinary excretion, and a decrease in the volume of distribution without a significant alteration of cefazolin binding to serum protein.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1987 PMID： 3606068 PMCID： PMC174795 DOI： 10.1128/AAC.31.4.635

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

1. Myxoedema: an autopsy report with histochemical observations on the nature of the mucoid infiltrations.

Authors: D B BREWER
Journal: J Pathol Bacteriol Date: 1951-07

2. Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.

Authors: R Benveniste; J Davies
Journal: Biochemistry Date: 1971-05-11 Impact factor: 3.162

3. Pharmacokinetic data. Pharmacokinetic parameters estimated from intravenous data by uniform methods and some of their uses.

Authors: J G Wagner
Journal: J Pharmacokinet Biopharm Date: 1977-04

Review 4. Changing patterns of hospital infections: implications for therapy. Changing concepts and new applications of antibiotic pharmacokinetics.

Authors: W A Craig; B Vogelman
Journal: Am J Med Date: 1984-07-31 Impact factor: 4.965

Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans.

1. Myxoedema: an autopsy report with histochemical observations on the nature of the mucoid infiltrations.

2. Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.

3. Pharmacokinetic data. Pharmacokinetic parameters estimated from intravenous data by uniform methods and some of their uses.

Review 4. Changing patterns of hospital infections: implications for therapy. Changing concepts and new applications of antibiotic pharmacokinetics.

5. Effusions into body cavities in hypothyroidism.

6. Determination of cephalosporins in biological material by reversed-phase liquid column chromatography.

7. Effects of phenylbutazone on extravascular diffusion, protein binding and urinary excretion of cefazolin in rabbits.

8. Effects of furosemide, piretanide, and water loading on urinary excretion of cefazolin in humans.

9. Mechanisms of edema formation in myxedema--increased protein extravasation and relatively slow lymphatic drainage.

10. Penetration of cefazolin, cephaloridine, and cefamandole into interstitial fluid in rabbits.

1. The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance.