Alireza Zali1, Mahsa Motavaf1, Saeid Safari2, Narges Ebrahimi3, Mahsa Ghajarzadeh4,5, Reza Jalili Khoshnood1, Omid Mirmosayyeb6,7. 1. Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Comprehensive Center of Excellence, Shohada-E-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Qods Sq., Building no 1, 4th floor, Tajrish, Tehran, Iran. 2. Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Comprehensive Center of Excellence, Shohada-E-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Qods Sq., Building no 1, 4th floor, Tajrish, Tehran, Iran. drsafari.s@gmail.com. 3. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 4. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. 5. Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran. 6. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 7. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
INTRODUCTION: The prevalence of restless legs syndrome (RLS) is reported to vary in patients with multiple sclerosis (MS) in studies which are conducted in different populations. The goal of this systematic review and meta-analysis is to update the prevalence of RLS in MS cases. METHODS: We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, Google Scholar, and gray literature including references from identified studies and conference abstracts which were published up to June 2021. Data on the total number of participants, first author, country, disease duration, number of controls, mean patient age, male and female numbers, mean EDSS, and number of cases and/or controls with RLS were extracted from the included studies. RESULTS: The literature search revealed 855 articles; after deleting duplicates, 530 remained. For the meta-analysis, 75 studies were included (Fig. 1). In six articles, the authors did not differentiate between CIS and MS cases when reporting RLS cases. In total, 15,411 MS/CIS patients were evaluated and 4309 had RLS. The pooled prevalence of RLS was 28% (95% CI: 24-33%). The pooled prevalence of RLS in men was 22% (95% CI: 17-26%), and the pooled prevalence of RLS in women was 30% (95% CI: 25-35%). The pooled prevalence of RLS in controls was 8% (95% CI: 6-10%). CONCLUSION: The results of this systematic review and meta-analysis show that the pooled prevalence of RLS is 28% in MS cases and 8%. The pooled prevalence is higher in women than men (30% vs 22%).
INTRODUCTION: The prevalence of restless legs syndrome (RLS) is reported to vary in patients with multiple sclerosis (MS) in studies which are conducted in different populations. The goal of this systematic review and meta-analysis is to update the prevalence of RLS in MS cases. METHODS: We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, Google Scholar, and gray literature including references from identified studies and conference abstracts which were published up to June 2021. Data on the total number of participants, first author, country, disease duration, number of controls, mean patient age, male and female numbers, mean EDSS, and number of cases and/or controls with RLS were extracted from the included studies. RESULTS: The literature search revealed 855 articles; after deleting duplicates, 530 remained. For the meta-analysis, 75 studies were included (Fig. 1). In six articles, the authors did not differentiate between CIS and MS cases when reporting RLS cases. In total, 15,411 MS/CIS patients were evaluated and 4309 had RLS. The pooled prevalence of RLS was 28% (95% CI: 24-33%). The pooled prevalence of RLS in men was 22% (95% CI: 17-26%), and the pooled prevalence of RLS in women was 30% (95% CI: 25-35%). The pooled prevalence of RLS in controls was 8% (95% CI: 6-10%). CONCLUSION: The results of this systematic review and meta-analysis show that the pooled prevalence of RLS is 28% in MS cases and 8%. The pooled prevalence is higher in women than men (30% vs 22%).
Authors: Richard P Allen; Daniel L Picchietti; Diego Garcia-Borreguero; William G Ondo; Arthur S Walters; John W Winkelman; Marco Zucconi; Raffaele Ferri; Claudia Trenkwalder; Hochang B Lee Journal: Sleep Med Date: 2014-05-17 Impact factor: 3.492
Authors: Tobias Monschein; Christian Schestak; Cornelia Schillerwein-Kral; Fritz Leutmezer; Thomas Berger; Gabriel Bsteh; Stefan Seidel Journal: Mult Scler Relat Disord Date: 2021-03-21 Impact factor: 4.339
Authors: Amirreza Azimi; Rozita Doosti; Sara Mohammad Vali Samani; Bita Roostaei; Sara Hamtaei Gashti; Samira Navardi; Mahsa Ghajarzadeh Journal: Int J Prev Med Date: 2021-05-27
Authors: Payam Sarraf; Sepeher Azizi; Abdorreza Naser Moghaddasi; Mohammad Ali Sahraian; Abbas Tafakhori; Mahsa Ghajarzadeh Journal: Int J Prev Med Date: 2014-12
Authors: Pietro Amedeo Modesti; Gianpaolo Reboldi; Francesco P Cappuccio; Charles Agyemang; Giuseppe Remuzzi; Stefano Rapi; Eleonora Perruolo; Gianfranco Parati Journal: PLoS One Date: 2016-01-25 Impact factor: 3.240