Pingping Ning1, Fayun Hu2, Baiyuan Yang3, Qiuyan Shen4, Quanzhen Zhao5, Hongyan Huang6, Ran An7, Yalan Chen8, Hui Wang9, Xinglong Yang10, Yanming Xu11. 1. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China. Electronic address: npp529@126.com. 2. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China. Electronic address: hufayun2006@163.com. 3. Department of Neurology, Seventh People's Hospital of Chengdu, No. 1, Twelve Middle Street, Wuhou District, Chengdu, Sichuan Province, 610041, PR China. Electronic address: 514562706@qq.com. 4. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China. Electronic address: 3523443731@qq.com. 5. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China. Electronic address: 1021996311@qq.com. 6. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China. Electronic address: 849074084@qq.com. 7. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China. Electronic address: neuroanr@163.com. 8. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China. Electronic address: 625651047@qq.com. 9. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China. Electronic address: 838286121@qq.com. 10. Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, 295 Xi Change Road, Kunming, Yunnan Province, 650032, PR China. Electronic address: yxldoc11@163.com. 11. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China. Electronic address: neuroxym999@163.com.
Abstract
OBJECTIVE: Multiple sclerosis (MS) is related to the demyelination of intracranial nerves at multiple sites, while restless legs syndrome (RLS) appears to be caused by dysfunction of the dopaminergic system. Since RLS prevalence is higher among MS patients than in the general population, we carried out an updated meta-analysis to understand whether the two diseases might be associated. METHOD: Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases were searched for observational and case-controlled studies of RLS prevalence in MS. Eligible studies were meta-analyzed using Stata 12.0. RESULTS: Pooled RLS prevalence among MS patients of various ethnicities was 26%, and prevalence was lower in Asia (20%) than outside Asia (27%). Prevalence was higher among cross-sectional studies (30%) than among case-control studies (23%). RLS prevalence was higher among female than male MS patients (26% vs. 17%), and it was higher among MS patients than among healthy controls (OR 3.96, 95%CI 3.29-4.77, p < 0.001). CONCLUSION: Our meta-analysis updates the most recent meta-analysis in 2013 and provides perhaps the first reliable pooled estimate of RLS prevalence in MS. The available evidence strongly suggests that RLS risk is higher among MS patients than healthy controls.
OBJECTIVE:Multiple sclerosis (MS) is related to the demyelination of intracranial nerves at multiple sites, while restless legs syndrome (RLS) appears to be caused by dysfunction of the dopaminergic system. Since RLS prevalence is higher among MSpatients than in the general population, we carried out an updated meta-analysis to understand whether the two diseases might be associated. METHOD: Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases were searched for observational and case-controlled studies of RLS prevalence in MS. Eligible studies were meta-analyzed using Stata 12.0. RESULTS: Pooled RLS prevalence among MSpatients of various ethnicities was 26%, and prevalence was lower in Asia (20%) than outside Asia (27%). Prevalence was higher among cross-sectional studies (30%) than among case-control studies (23%). RLS prevalence was higher among female than male MSpatients (26% vs. 17%), and it was higher among MSpatients than among healthy controls (OR 3.96, 95%CI 3.29-4.77, p < 0.001). CONCLUSION: Our meta-analysis updates the most recent meta-analysis in 2013 and provides perhaps the first reliable pooled estimate of RLS prevalence in MS. The available evidence strongly suggests that RLS risk is higher among MSpatients than healthy controls.
Authors: Katie L J Cederberg; Brenda Jeng; Jeffer E Sasaki; Tiffany J Braley; Arthur S Walters; Robert W Motl Journal: J Neurol Sci Date: 2019-10-12 Impact factor: 3.181
Authors: Katie L J Cederberg; Arthur S Walters; Amy W Amara; Tiffany J Braley; Morgan L Schuetz; Brianna G Mathison; Robert W Motl Journal: Sleep Med Date: 2021-06-16 Impact factor: 4.842