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Literature DB >> 36043335

The sun, cholesterol and Orai1 conspire in melanoma.

Abstract

How does skin cancer become metastatic? A recent study by Gross et al (2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca2+ influx by Orai1, causing protein O-GlcNAcylation that promotes transformation to invasive melanoma. Published 2022. This article is a U.S. Government work and is in the public domain in the USA.

Entities: Chemical

Mesh：

Substances：

Year: 2022 PMID： 36043335 PMCID： PMC9531301 DOI： 10.15252/embj.2022112250

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 14.012

12 in total

Review 1. Store-Operated Calcium Channels.

Authors: Murali Prakriya; Richard S Lewis
Journal: Physiol Rev Date: 2015-10 Impact factor: 37.312

Review 2. Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins.

Authors: Amita Arora; Juuso H Taskinen; Vesa M Olkkonen
Journal: Prog Lipid Res Date: 2022-01-06 Impact factor: 16.195

3. MCU controls melanoma progression through a redox-controlled phenotype switch.

Authors: Ioana Stejerean-Todoran; Katharina Zimmermann; Christine S Gibhardt; Adina Vultur; Christian Ickes; Batool Shannan; Zuriñe Bonilla Del Rio; Anna Wölling; Sabrina Cappello; Hsu-Min Sung; Magdalena Shumanska; Xin Zhang; Maithily Nanadikar; Muhammad U Latif; Anna Wittek; Felix Lange; Andrea Waters; Patricia Brafford; Jörg Wilting; Henning Urlaub; Dörthe M Katschinski; Peter Rehling; Christof Lenz; Stefan Jakobs; Volker Ellenrieder; Alexander Roesch; Michael P Schön; Meenhard Herlyn; Hedwig Stanisz; Ivan Bogeski
Journal: EMBO Rep Date: 2022-09-26 Impact factor: 9.071

4. Suppression of Ca²⁺ signaling enhances melanoma progression.

Authors: Scott Gross; Robert Hooper; Dhanendra Tomar; Alexander P Armstead; No'ad Shanas; Pranava Mallu; Hinal Joshi; Suravi Ray; Parkson Lee-Gau Chong; Igor Astsaturov; Jeffrey M Farma; Kathy Q Cai; Kumaraswamy Naidu Chitrala; John W Elrod; M Raza Zaidi; Jonathan Soboloff
Journal: EMBO J Date: 2022-08-30 Impact factor: 14.012

5. The sun, cholesterol and Orai1 conspire in melanoma.

Authors: Woo Young Chung; Shmuel Muallem
Journal: EMBO J Date: 2022-08-31 Impact factor: 14.012

6. Cholesterol modulates Orai1 channel function.

Authors: Isabella Derler; Isaac Jardin; Peter B Stathopulos; Martin Muik; Marc Fahrner; Vasilina Zayats; Saurabh K Pandey; Michael Poteser; Barbara Lackner; Marketa Absolonova; Rainer Schindl; Klaus Groschner; Rüdiger Ettrich; Mitsu Ikura; Christoph Romanin
Journal: Sci Signal Date: 2016-01-26 Impact factor: 8.192

Review 7. The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease.

Authors: Michael J Berridge
Journal: Physiol Rev Date: 2016-10 Impact factor: 37.312

8. Redox signals at the ER-mitochondria interface control melanoma progression.

Authors: Xin Zhang; Christine S Gibhardt; Thorsten Will; Hedwig Stanisz; Christina Körbel; Miso Mitkovski; Ioana Stejerean; Sabrina Cappello; David Pacheu-Grau; Jan Dudek; Nasser Tahbaz; Lucas Mina; Thomas Simmen; Matthias W Laschke; Michael D Menger; Michael P Schön; Volkhard Helms; Barbara A Niemeyer; Peter Rehling; Adina Vultur; Ivan Bogeski
Journal: EMBO J Date: 2019-07-15 Impact factor: 11.598

The sun, cholesterol and Orai1 conspire in melanoma.

Review 1. Store-Operated Calcium Channels.

Review 2. Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins.

3. MCU controls melanoma progression through a redox-controlled phenotype switch.

4. Suppression of Ca²⁺ signaling enhances melanoma progression.

5. The sun, cholesterol and Orai1 conspire in melanoma.

6. Cholesterol modulates Orai1 channel function.

Review 7. The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease.

8. Redox signals at the ER-mitochondria interface control melanoma progression.

Review 9. The Role of Calcium Signaling in Melanoma.

Review 10. Store Operated Calcium Entry in Cell Migration and Cancer Metastasis.

1. The sun, cholesterol and Orai1 conspire in melanoma.

The sun, cholesterol and Orai1 conspire in melanoma.

Review 1. Store-Operated Calcium Channels.

Review 2. Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins.

3. MCU controls melanoma progression through a redox-controlled phenotype switch.

4. Suppression of Ca2+ signaling enhances melanoma progression.

5. The sun, cholesterol and Orai1 conspire in melanoma.

6. Cholesterol modulates Orai1 channel function.

Review 7. The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease.

8. Redox signals at the ER-mitochondria interface control melanoma progression.

Review 9. The Role of Calcium Signaling in Melanoma.

Review 10. Store Operated Calcium Entry in Cell Migration and Cancer Metastasis.

1. The sun, cholesterol and Orai1 conspire in melanoma.

4. Suppression of Ca²⁺ signaling enhances melanoma progression.