Haya H Al-Ani1,2, Joanne L Sims1, Rachael L Niederer3,4. 1. Department of Ophthalmology, Auckland District Health Board, Auckland, New Zealand. 2. Department of Ophthalmology, University of Auckland, Auckland, New Zealand. 3. Department of Ophthalmology, Auckland District Health Board, Auckland, New Zealand. RachaelN@adhb.govt.nz. 4. Department of Ophthalmology, University of Auckland, Auckland, New Zealand. RachaelN@adhb.govt.nz.
Abstract
OBJECTIVES: To evaluate the long term complications and vision loss in HLA-B27 uveitis. METHODS: Retrospective review of subjects with HLA-B27 uveitis in a public tertiary centre between January 2008 and 2020. RESULTS: 562 HLA-B27-positive subjects (834 eyes) had mean follow-up of 9.8 years (8173.2 eye-years). Median visual acuity at ten years was 0.1 logMAR (IQR 0.0-0.1). Complications occurred in 404 eyes (48.4%): posterior synechiae (39.7%), cataract (22.1%), elevated intraocular pressure (15.5%), cystoid macular oedema (6.0%). Permanent moderate vision loss ( ≤ 0.4 logMAR) due to uveitis occurred in 14 eyes (1.7%) and severe vision loss (≤ 1.0 logMAR) in 7 eyes (0.8%). Complications were more common with older age (OR 1.017 p = 0.016), chronic inflammation (OR 5.272 p < 0.001) and intermediate uveitis (OR 5.982 p < 0.001). CONCLUSIONS: Complications are frequent in HLA-B27 uveitis, especially in older subjects, chronic inflammation and intermediate uveitis. Despite this, the majority of subjects maintain good visual prognosis.
OBJECTIVES: To evaluate the long term complications and vision loss in HLA-B27 uveitis. METHODS: Retrospective review of subjects with HLA-B27 uveitis in a public tertiary centre between January 2008 and 2020. RESULTS: 562 HLA-B27-positive subjects (834 eyes) had mean follow-up of 9.8 years (8173.2 eye-years). Median visual acuity at ten years was 0.1 logMAR (IQR 0.0-0.1). Complications occurred in 404 eyes (48.4%): posterior synechiae (39.7%), cataract (22.1%), elevated intraocular pressure (15.5%), cystoid macular oedema (6.0%). Permanent moderate vision loss ( ≤ 0.4 logMAR) due to uveitis occurred in 14 eyes (1.7%) and severe vision loss (≤ 1.0 logMAR) in 7 eyes (0.8%). Complications were more common with older age (OR 1.017 p = 0.016), chronic inflammation (OR 5.272 p < 0.001) and intermediate uveitis (OR 5.982 p < 0.001). CONCLUSIONS: Complications are frequent in HLA-B27 uveitis, especially in older subjects, chronic inflammation and intermediate uveitis. Despite this, the majority of subjects maintain good visual prognosis.
Authors: Ning Cheung; Shu-Pei Tan; Shu Yen Lee; Gemmy Chui Ming Cheung; Gavin Tan; Neelam Kumar; Ching-Yu Cheng; Tien Yin Wong Journal: Br J Ophthalmol Date: 2016-06-24 Impact factor: 4.638
Authors: Oren Tomkins-Netzer; Susan L Lightman; Alyce E Burke; Elizabeth A Sugar; Lyndell L Lim; Glenn J Jaffe; Michael M Altaweel; John H Kempen; Janet T Holbrook; Douglas A Jabs Journal: Ophthalmology Date: 2020-09-10 Impact factor: 14.277