Literature DB >> 3600647

Identification and characterization of cDNA clones encoding two homologous proteins that are part of the asialoglycoprotein receptor.

M McPhaul, P Berg.   

Abstract

The asialoglycoprotein receptor (ASGP-R) from rat liver contains the following three distinct protein species when it is analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis: RHL1 (42 kilodaltons), RHL2 (49 kilodaltons), and RHL3 (54 kilodaltons). In this paper we describe the isolation of cDNA clones encoding RHL1 and RHL2 from a cDNA library constructed from rat liver mRNA. A comparison of the predicted coding sequence for RHL2 with that for RHL1 showed that these sequences are highly homologous. The library also contained numerous cDNA clones for both RHL1 and RHL2 that were derived from unspliced precursor mRNAs. Differential splicing at the 5' end of the RHL1 transcript was inferred from the finding that two different types of RHL1 cDNA were identified, each having a different 5' terminus.

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Year:  1987        PMID： 3600647      PMCID： PMC365287          DOI： 10.1128/mcb.7.5.1841-1847.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  19 in total

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2.  The rat liver asialoglycoprotein receptor polypeptide must be inserted into a microsome to achieve its active conformation.

Authors:  E C Hsueh; E C Holland; G M Carrera; K Drickamer
Journal:  J Biol Chem       Date:  1986-04-15       Impact factor: 5.157

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Authors:  J O Leung; E C Holland; K Drickamer
Journal:  J Biol Chem       Date:  1985-10-15       Impact factor: 5.157

4.  Formation of functional asialoglycoprotein receptor after transfection with cDNAs encoding the receptor proteins.

Authors:  M McPhaul; P Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

5.  Direct evidence for the transmembrane orientation of the hepatic glycoprotein receptors.

Authors:  K B Chiacchia; K Drickamer
Journal:  J Biol Chem       Date:  1984-12-25       Impact factor: 5.157

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Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

7.  Primary structure of the rat liver asialoglycoprotein receptor. Structural evidence for multiple polypeptide species.

Authors:  K Drickamer; J F Mamon; G Binns; J O Leung
Journal:  J Biol Chem       Date:  1984-01-25       Impact factor: 5.157

8.  Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.

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9.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

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Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

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Authors:  M Spiess; H F Lodish
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205
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  8 in total

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2.  Receptor-mediated endocytosis of asialoglycoproteins and diferric transferrin is independent of second messengers.

Authors:  R J Sharma; N M Woods; P H Cobbold; D A Grant
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Review 4.  An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

Authors:  M Kozak
Journal:  Nucleic Acids Res       Date:  1987-10-26       Impact factor: 16.971

5.  Interaction of egg-white glycoproteins and their oligosaccharides with the monomer and the hexamer of chicken liver lectin. A multivalent oligosaccharide-combining site exists within the carbohydrate-recognition domain.

Authors:  V E Piskarev; J Navrátil; H Karásková; K Bezouska; J Kocourek
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6.  The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acid alpha 2,6GalNAc.

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7.  Rat liver beta-glucuronidase. cDNA cloning, sequence comparisons and expression of a chimeric protein in COS cells.

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Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857

8.  The H1 and H2 polypeptides associate to form the asialoglycoprotein receptor in human hepatoma cells.

Authors:  J Bischoff; S Libresco; M A Shia; H F Lodish
Journal:  J Cell Biol       Date:  1988-04       Impact factor: 10.539
  8 in total

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