Qiu Ling Zang1, Jin Hua Zheng2, Jian Jun Ma3, Qi Zhang1, Pei Pei Huang1, Nan Nan Shen1, Wang Miao4. 1. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 1 Jian She East Road, Zhengzhou, 450007, Henan Province, People's Republic of China. 2. Department of Neurology, Henan Provincial People's Hospital, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China. 3. Department of Neurology, Henan Provincial People's Hospital, No. 7, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China. majj@zzu.edu.cn. 4. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 1 Jian She East Road, Zhengzhou, 450007, Henan Province, People's Republic of China. miaowang7211@126.com.
Abstract
INTRODUCTION: Restless legs syndrome (RLS) is a common non-motor symptom in Parkinson's disease (PD), but its pathogenesis remains unclear. This study aimed to explore the potential neural substrates of RLS in a large sample of patients with PD. METHODS: A total of 42 patients with PD with RLS and 124 patients with PD without RLS were prospectively recruited at our hospital between February 2019 and October 2020 and underwent structural and resting-state functional magnetic resonance imaging. Differences between the two patient groups were assessed using voxel-based morphometry and functional connectivity analysis. PD duration, Part III of the Movement Disorder Society's Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) score, and levodopa equivalent daily dose were treated as covariates. RESULTS: Patients with PD with RLS had significantly larger gray matter volume in the bilateral posterior cingulate cortex than patients with PD without RLS (FDR-adjusted P < 0.05). Compared to patients without RLS, those with RLS had significantly lower functional connectivity between the left central opercular cortex and the bilateral precentral gyri and postcentral gyri (FDR-adjusted P < 0.001). CONCLUSION: Our study provides the first evidence that in patients with PD, RLS is associated with significantly larger gray matter volume in the posterior cingulate cortex and lower resting-state functional connectivity within the sensorimotor network. Our results may help clarify the pathophysiology of RLS in PD and identify possible therapeutic targets.
INTRODUCTION: Restless legs syndrome (RLS) is a common non-motor symptom in Parkinson's disease (PD), but its pathogenesis remains unclear. This study aimed to explore the potential neural substrates of RLS in a large sample of patients with PD. METHODS: A total of 42 patients with PD with RLS and 124 patients with PD without RLS were prospectively recruited at our hospital between February 2019 and October 2020 and underwent structural and resting-state functional magnetic resonance imaging. Differences between the two patient groups were assessed using voxel-based morphometry and functional connectivity analysis. PD duration, Part III of the Movement Disorder Society's Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) score, and levodopa equivalent daily dose were treated as covariates. RESULTS: Patients with PD with RLS had significantly larger gray matter volume in the bilateral posterior cingulate cortex than patients with PD without RLS (FDR-adjusted P < 0.05). Compared to patients without RLS, those with RLS had significantly lower functional connectivity between the left central opercular cortex and the bilateral precentral gyri and postcentral gyri (FDR-adjusted P < 0.001). CONCLUSION: Our study provides the first evidence that in patients with PD, RLS is associated with significantly larger gray matter volume in the posterior cingulate cortex and lower resting-state functional connectivity within the sensorimotor network. Our results may help clarify the pathophysiology of RLS in PD and identify possible therapeutic targets.
Authors: Ambra Stefani; Thomas Mitterling; Anna Heidbreder; Ruth Steiger; Christian Kremser; Birgit Frauscher; Elke R Gizewski; Werner Poewe; Birgit Högl; Christoph Scherfler Journal: Sleep Date: 2019-12-24 Impact factor: 5.849
Authors: Christopher J Earley; Hiroto Kuwabara; Dean F Wong; Charlene Gamaldo; Rachel Salas; James Brasic; Hayden T Ravert; Robert F Dannals; Richard P Allen Journal: Sleep Date: 2011-03-01 Impact factor: 5.849