Xinglong Yang1, Bin Liu2, Hao Shen3, Shimei Li4, Quanzhen Zhao5, Ran An5, Fayun Hu5, Hui Ren6, Yanming Xu7, Zhong Xu8. 1. Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China; Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China. 2. Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China. 3. Department of Rehabilitation, The Second People's Hospital of Jiang You, Mian Yang, People's Republic of China. 4. Department of Anesthesia, Kunming Xishan District People's Hospital, Kunming, People's Republic of China. 5. Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China. 6. Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China. Electronic address: huiren2006@163.com. 7. Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China. Electronic address: neuroxym999@163.com. 8. Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China. Electronic address: xuzhong118@126.com.
Abstract
OBJECTIVE: Restless legs syndrome (RLS) and Parkinson's disease (PD) are common neurological disorders that respond to dopaminergic therapy. RLS prevalence among people with PD varies widely (0-38%) in the literature, complicating efforts to understand whether the two diseases might be associated. METHOD: The databases Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were searched for observational and case-control studies of RLS prevalence in PD. Eligible studies were meta-analyzed using Stata 12.0. RESULTS: Pooled RLS prevalence in PD among various patient populations was 14%, and prevalence in Asia (12%) was slightly lower than outside Asia (16%). Prevalence was higher among patients who had previously received PD treatment (15%) than among drug-naïve patients (11%). Prevalence of RLS was higher in female PD patients (13%) than in male patients (11%). RLS prevalence was much higher among PD patients than among healthy controls (OR 2.86, 95% CI 2.10-3.90; p < 0.001). CONCLUSION: This meta-analysis may provide the first reliable pooled estimate of RLS prevalence in PD, and strong evidence that RLS risk is higher among PD patients than among healthy individuals.
OBJECTIVE:Restless legs syndrome (RLS) and Parkinson's disease (PD) are common neurological disorders that respond to dopaminergic therapy. RLS prevalence among people with PD varies widely (0-38%) in the literature, complicating efforts to understand whether the two diseases might be associated. METHOD: The databases Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were searched for observational and case-control studies of RLS prevalence in PD. Eligible studies were meta-analyzed using Stata 12.0. RESULTS: Pooled RLS prevalence in PD among various patient populations was 14%, and prevalence in Asia (12%) was slightly lower than outside Asia (16%). Prevalence was higher among patients who had previously received PD treatment (15%) than among drug-naïve patients (11%). Prevalence of RLS was higher in female PDpatients (13%) than in male patients (11%). RLS prevalence was much higher among PDpatients than among healthy controls (OR 2.86, 95% CI 2.10-3.90; p < 0.001). CONCLUSION: This meta-analysis may provide the first reliable pooled estimate of RLS prevalence in PD, and strong evidence that RLS risk is higher among PDpatients than among healthy individuals.
Authors: Sohaila Alshimemeri; Daniel G Di Luca; Diana A Olszewska; Eoin Mulroy; Kailash P Bhatia; Susan H Fox; Anthony E Lang Journal: Mov Disord Clin Pract Date: 2022-06-10
Authors: Donald L Bliwise; Elias G Karroum; Sophia A Greer; Stewart A Factor; Lynn Marie Trotti Journal: J Parkinsons Dis Date: 2022 Impact factor: 5.520