Literature DB >> 35992511

Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse.

Marie N S Gendy1,2, Clement Zai3,4,5, Bernard Le Foll1,6,7,8,2,3,9, James L Kennedy3,4.   

Abstract

Alcohol use disorder is a complex disorder that is influenced by genetic factors. The non-synonymous single-nucleotide polymorphism (SNP) rs1799971 in exon 1 in opioid receptor OPRM1 was extensively studied in patients with alcohol dependence with mixed findings. Moreover, studies showed that opioid receptor polymorphism might play a role in the pathophysiology of schizophrenia. Our results suggest that rs1799971 SNP is not significantly associated with alcohol dependence in our sample of Schizophrenia patients of European ancestry.

Entities:  

Keywords:  Mu opioid receptor gene (OPRM1); alcohol dependence; polymorphism; schizophrenia

Year:  2019        PMID： 35992511      PMCID： PMC9387363          DOI： 10.1097/cxa.0000000000000069

Source DB:  PubMed          Journal:  Can J Addict        ISSN： 2368-4720


  54 in total

Review 1.  Is there a common molecular pathway for addiction?

Authors:  Eric J Nestler
Journal:  Nat Neurosci       Date:  2005-11       Impact factor: 24.884

2.  Mu-opioid receptor and CREB activation are required for nicotine reward.

Authors:  Carrie L Walters; Jessica N Cleck; Yuo-chen Kuo; Julie A Blendy
Journal:  Neuron       Date:  2005-06-16       Impact factor: 17.173

3.  Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey.

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Journal:  Arch Gen Psychiatry       Date:  1997-04

4.  Alcohol consumption with age: a cross-sectional and longitudinal study of the Atherosclerosis Risk in Communities (ARIC) study, 1987-1995.

Authors:  M L Eigenbrodt; T H Mosley; R G Hutchinson; R L Watson; L E Chambless; M Szklo
Journal:  Am J Epidemiol       Date:  2001-06-01       Impact factor: 4.897

5.  Drinking over the life course within gender and ethnic groups: a hyperparametric analysis.

Authors:  F W Johnson; P J Gruenewald; A J Treno; G A Taff
Journal:  J Stud Alcohol       Date:  1998-09

Review 6.  OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.

Authors:  Stephen D Mague; Julie A Blendy
Journal:  Drug Alcohol Depend       Date:  2010-01-13       Impact factor: 4.492

7.  The interaction of reward genes with environmental factors in contribution to alcoholism in mexican americans.

Authors:  Yanlei Du; Yu-Jui Yvonne Wan
Journal:  Alcohol Clin Exp Res       Date:  2009-09-17       Impact factor: 3.455

8.  Tests of opioid deficiency hypotheses of alcoholism.

Authors:  L D Reid; J D Delconte; M L Nichols; E J Bilsky; C L Hubbell
Journal:  Alcohol       Date:  1991 Jul-Aug       Impact factor: 2.405

9.  A microdialysis profile of beta-endorphin and catecholamines in the rat nucleus accumbens following alcohol administration.

Authors:  Peter W Marinelli; Rémi Quirion; Christina Gianoulakis
Journal:  Psychopharmacology (Berl)       Date:  2003-05-21       Impact factor: 4.530

10.  Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population.

Authors:  Saidan Ding; Bicheng Chen; Yong Zheng; Qin Lu; Leping Liu; Qǐ-Chuan Zhuge
Journal:  BMC Psychiatry       Date:  2013-04-05       Impact factor: 3.630
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