Juan Sendon-Lago1, Samuel Seoane1, Fatima Saleh2, Lucia Garcia-Caballero3, Maria E Arias4, Noemi Eiro5, Manuel Macia4, Francisco J Vizoso5, Roman Perez-Fernandez1, Jose Schneider6. 1. Department of Physiology-Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain. 2. Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon. 3. Department of Morphological Sciences, Universidade de Santiago de Compostela, Santiago de Compostela, Spain. 4. Department of Obstetrics & Gynecology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain. 5. Research Unit, Hospital Fundación de Jove, Gijón, Spain. 6. Department of Obstetrics & Gynecology, University of Valladolid, School of Medicine, Valladolid, Spain jose.schneider@uva.es.
Abstract
BACKGROUND/AIM: Ovarian cancer is the most lethal of all gynecological cancers, despite advances in surgical techniques and medical treatments. During the last years, therapies based on mesenchymal stem cells and particularly their secretome (conditioned medium, CM) have emerged as promising treatments for various types of tumors. MATERIALS AND METHODS: In the present study, we evaluated the in vivo antitumor effect of human uterine cervical stem cell conditioned medium (hUCESC-CM) after intraperitoneal administration in an ovarian cancer mouse model. RESULTS: We found that intraperitoneal injection of hUCESC-CM in immunodeficient mice, injected fifty days previously with the human ovarian adenocarcinoma SKOV-3 cell line, significantly reduced abdominal tumor growth, and significantly increased overall survival, compared to control mice. CONCLUSION: hUCESC-CM could be an alternative approach to intraperitoneal treatment of ovarian cancer, either administered alone and/or with conventional chemotherapy. Copyright
BACKGROUND/AIM: Ovarian cancer is the most lethal of all gynecological cancers, despite advances in surgical techniques and medical treatments. During the last years, therapies based on mesenchymal stem cells and particularly their secretome (conditioned medium, CM) have emerged as promising treatments for various types of tumors. MATERIALS AND METHODS: In the present study, we evaluated the in vivo antitumor effect of human uterine cervical stem cell conditioned medium (hUCESC-CM) after intraperitoneal administration in an ovarian cancer mouse model. RESULTS: We found that intraperitoneal injection of hUCESC-CM in immunodeficient mice, injected fifty days previously with the human ovarian adenocarcinoma SKOV-3 cell line, significantly reduced abdominal tumor growth, and significantly increased overall survival, compared to control mice. CONCLUSION: hUCESC-CM could be an alternative approach to intraperitoneal treatment of ovarian cancer, either administered alone and/or with conventional chemotherapy. Copyright
Authors: Maria A Bermudez; Juan Sendon-Lago; Noemi Eiro; Mercedes Treviño; Francisco Gonzalez; Eva Yebra-Pimentel; Maria Jesus Giraldez; Manuel Macia; Maria Luz Lamelas; Jorge Saa; Francisco Vizoso; Roman Perez-Fernandez Journal: Invest Ophthalmol Vis Sci Date: 2015-01-22 Impact factor: 4.799
Authors: José Schneider; Estibaliz Mateo; Cristina Marcos-Arias; Noemi Eiró; Francisco Vizoso; Román Pérez-Fernández; Elena Eraso; Guillermo Quindós Journal: Front Microbiol Date: 2018-11-21 Impact factor: 5.640
Authors: C Khalil; M Moussa; A Azar; J Tawk; J Habbouche; R Salameh; A Ibrahim; N Alaaeddine Journal: J Ovarian Res Date: 2019-07-27 Impact factor: 4.234
Authors: Joseph G Skeate; Mikk E Otsmaa; Ruben Prins; Daniel J Fernandez; Diane M Da Silva; W Martin Kast Journal: Front Immunol Date: 2020-05-15 Impact factor: 7.561
Authors: Anne T Knisely; Caryn M St Clair; June Y Hou; Fady Khoury Collado; Dawn L Hershman; Jason D Wright; Alexander Melamed Journal: JAMA Netw Open Date: 2020-09-01