Literature DB >> 35978572

Analysis of Caenorhabditis elegans Aging-related Neurodegeneration in Chemosensory Neurons.

Cira Crespo1, Roberto Grau1.   

Abstract

Aging and neuronal deterioration constitute important risk factors for the development of neuronal-related diseases, such as different dementia. The nematode Caenorhabditis elegans has emerged as a popular model system for studying neurodegeneration diseases, due to its complete neuronal connectivity map. DiI is a red fluorescent dye that can fill the worm amphid neurons and enables the visualization of their neurodegeneration over time. This protocol provides an efficient, fast, and safe method to stain worm amphid neurons to highlight the chemosensory structures of live nematodes.
Copyright © 2022 The Authors; exclusive licensee Bio-protocol LLC.

Entities:  

Keywords:  Aging ; Caenorhabditis elegans ; DiI ; Neurodegeneration ; Neurons

Year:  2022        PMID： 35978572      PMCID： PMC9350917          DOI： 10.21769/BioProtoc.4473

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  11 in total

Review 1.  Maintenance of C. elegans.

Authors:  Theresa Stiernagle
Journal:  WormBook       Date:  2006-02-11

Review 2.  The aging brain.

Authors:  Bruce A Yankner; Tao Lu; Patrick Loerch
Journal:  Annu Rev Pathol       Date:  2008       Impact factor: 23.472

3.  Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.

Authors:  Marton Lorant Toth; Ilija Melentijevic; Leena Shah; Aatish Bhatia; Kevin Lu; Amish Talwar; Haaris Naji; Carolina Ibanez-Ventoso; Piya Ghose; Angela Jevince; Jian Xue; Laura A Herndon; Gyan Bhanot; Chris Rongo; David H Hall; Monica Driscoll
Journal:  J Neurosci       Date:  2012-06-27       Impact factor: 6.167

4.  Basic Caenorhabditis elegans methods: synchronization and observation.

Authors:  Montserrat Porta-de-la-Riva; Laura Fontrodona; Alberto Villanueva; Julián Cerón
Journal:  J Vis Exp       Date:  2012-06-10       Impact factor: 1.355

5.  Effect of temperature and calcium on transneuronal diffusion of DiI in fixed brain preparations.

Authors:  M H Hofmann; H Bleckmann
Journal:  J Neurosci Methods       Date:  1999-04-01       Impact factor: 2.390

6.  Bacillus Subtilis Delays Neurodegeneration and Behavioral Impairment in the Alzheimer's Disease Model Caenorhabditis Elegans.

Authors:  Sebastián Cogliati; Victoria Clementi; Marcos Francisco; Cira Crespo; Federico Argañaraz; Roberto Grau
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472

Review 7.  Genetic and Pharmacological Discovery for Alzheimer's Disease Using Caenorhabditis elegans.

Authors:  Edward F Griffin; Kim A Caldwell; Guy A Caldwell
Journal:  ACS Chem Neurosci       Date:  2017-10-25       Impact factor: 4.418

8.  A study in developing visual systems with a new method of staining neurones and their processes in fixed tissue.

Authors:  P Godement; J Vanselow; S Thanos; F Bonhoeffer
Journal:  Development       Date:  1987-12       Impact factor: 6.868

9.  Fluorescent carbocyanine dyes allow living neurons of identified origin to be studied in long-term cultures.

Authors:  M G Honig; R I Hume
Journal:  J Cell Biol       Date:  1986-07       Impact factor: 10.539

Review 10.  Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.

Authors:  Adanna G Alexander; Vanessa Marfil; Chris Li
Journal:  Front Genet       Date:  2014-09-05       Impact factor: 4.599
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