Literature DB >> 35970881

Structural keys unlock RAS-MAPK cellular signalling pathway.

Hugo Lavoie, Marc Therrien.   

Abstract

Entities:  

Keywords:  Molecular biology; Structural biology

Mesh：

Year:  2022        PMID： 35970881     DOI： 10.1038/d41586-022-02189-7

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   69.504


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  15 in total

1.  A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.

Authors:  Pablo Rodriguez-Viciana; Juan Oses-Prieto; Alma Burlingame; Mike Fried; Frank McCormick
Journal:  Mol Cell       Date:  2006-04-21       Impact factor: 17.970

Review 2.  RAS Proteins and Their Regulators in Human Disease.

Authors:  Dhirendra K Simanshu; Dwight V Nissley; Frank McCormick
Journal:  Cell       Date:  2017-06-29       Impact factor: 41.582

3.  Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy.

Authors:  Erin M Higgins; J Martijn Bos; Heather Mason-Suares; David J Tester; Jaeger P Ackerman; Calum A MacRae; Katia Sol-Church; Karen W Gripp; Raul Urrutia; Michael J Ackerman
Journal:  JCI Insight       Date:  2017-03-09

4.  Mammalian Ras interacts directly with the serine/threonine kinase Raf.

Authors:  A B Vojtek; S M Hollenberg; J A Cooper
Journal:  Cell       Date:  1993-07-16       Impact factor: 41.582

Review 5.  ERK signalling: a master regulator of cell behaviour, life and fate.

Authors:  Hugo Lavoie; Jessica Gagnon; Marc Therrien
Journal:  Nat Rev Mol Cell Biol       Date:  2020-06-23       Impact factor: 94.444

6.  The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.

Authors:  W Li; M Han; K L Guan
Journal:  Genes Dev       Date:  2000-04-15       Impact factor: 11.361

7.  A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair.

Authors:  Karen W Gripp; Kimberly A Aldinger; James T Bennett; Laura Baker; Jessica Tusi; Nina Powell-Hamilton; Deborah Stabley; Katia Sol-Church; Andrew E Timms; William B Dobyns
Journal:  Am J Med Genet A       Date:  2016-06-05       Impact factor: 2.802

8.  SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.

Authors:  D S Sieburth; Q Sun; M Han
Journal:  Cell       Date:  1998-07-10       Impact factor: 41.582

9.  Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.

Authors:  Viviana Cordeddu; Elia Di Schiavi; Len A Pennacchio; Avi Ma'ayan; Anna Sarkozy; Valentina Fodale; Serena Cecchetti; Alessio Cardinale; Joel Martin; Wendy Schackwitz; Anna Lipzen; Giuseppe Zampino; Laura Mazzanti; Maria C Digilio; Simone Martinelli; Elisabetta Flex; Francesca Lepri; Deborah Bartholdi; Kerstin Kutsche; Giovanni B Ferrero; Cecilia Anichini; Angelo Selicorni; Cesare Rossi; Romano Tenconi; Martin Zenker; Daniela Merlo; Bruno Dallapiccola; Ravi Iyengar; Paolo Bazzicalupo; Bruce D Gelb; Marco Tartaglia
Journal:  Nat Genet       Date:  2009-08-16       Impact factor: 38.330

10.  Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.

Authors:  Eunyoung Park; Shaun Rawson; Kunhua Li; Byeong-Won Kim; Scott B Ficarro; Gonzalo Gonzalez-Del Pino; Humayun Sharif; Jarrod A Marto; Hyesung Jeon; Michael J Eck
Journal:  Nature       Date:  2019-10-03       Impact factor: 49.962
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