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Literature DB >> 10783161

The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.

Abstract

Caenorhabditis elegans sur-8 encodes a positive regulator of Ras signaling. We investigated the mechanism by which the human Sur-8 homolog can positively regulate Ras-MAP kinase signaling in mammalian cells. Sur-8 expression enhances Ras- or EGF-induced Raf and ERK activation but has no effect on ERK activation induced by active Raf or MEK. Furthermore, Sur-8 expression does not increase AKT or JNK activation. Sur-8 interacts with Ras and Raf and is able to form a ternary complex with the two proteins. Thus, Sur-8 may function as a scaffold that enhances Ras-MAP kinase signal transduction by facilitating the interaction between Ras and Raf.

Entities: Gene Species

Mesh：

Substances：

Year: 2000 PMID： 10783161 PMCID： PMC316541

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

33 in total

The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.

1. Ras signal transduction pathway in Drosophila eye development.

2. Ras-Raf interaction: two-hybrid analysis.

3. Mammalian Ras interacts directly with the serine/threonine kinase Raf.

Review 4. Receptor protein-tyrosine kinases and their signal transduction pathways.

5. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.

6. Transformation of mammalian cells by constitutively active MAP kinase kinase.

7. Phosphatidylinositol-3-OH kinase as a direct target of Ras.

8. The stress-activated protein kinase subfamily of c-Jun kinases.

9. soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.

10. Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

Review 1. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.

2. Nud1p links astral microtubule organization and the control of exit from mitosis.

3. Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans.

4. Analysis of the eye developmental pathway in Drosophila using DNA microarrays.

5. Single-molecule imaging analysis of Ras activation in living cells.

6. Erbin inhibits TGF-β1-induced EMT in renal tubular epithelial cells through an ERK-dependent pathway.

Review 7. Mechanistic principles of RAF kinase signaling.

8. The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation.

9. Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase.

10. The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.