Literature DB >> 35966501

Metal Complexes for Therapeutic Applications.

Johannes Karges1, Ryjul W Stokes1, Seth M Cohen1.   

Abstract

Metal complexes have been widely used for applications in the chemical and physical sciences due to their unique electronic and stereochemical properties. For decades the use of metal complexes for medicinal applications has been postulated and demonstrated. The distinct characteristics of metal complexes, including their molecular geometries (that are not readily accessed by organic molecules), as well as their ligand exchange, redox, catalytic, and photophysical reactions, give these compounds the potential to interact and react with biomolecules in unique ways and by distinct mechanisms of action. Herein, the potential of metal complexes to act as components bioactive therapeutic compounds is discussed.

Entities:  

Keywords:  Bioinorganic Chemistry; Chemical Biology; Coordination Compounds; Enzyme Inhibitors; Metals in Medicine

Year:  2021        PMID: 35966501      PMCID: PMC9374106          DOI: 10.1016/j.trechm.2021.03.006

Source DB:  PubMed          Journal:  Trends Chem        ISSN: 2589-5974


  86 in total

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Journal:  J Chem Inf Comput Sci       Date:  2003 May-Jun

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Journal:  Chem Soc Rev       Date:  2015-10-21       Impact factor: 54.564

4.  Redox Stability Controls the Cellular Uptake and Activity of Ruthenium-Based Inhibitors of the Mitochondrial Calcium Uniporter (MCU).

Authors:  Joshua J Woods; James Lovett; Barry Lai; Hugh H Harris; Justin J Wilson
Journal:  Angew Chem Int Ed Engl       Date:  2020-02-28       Impact factor: 15.336

Review 5.  Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics.

Authors:  Zhen Yu; James A Cowan
Journal:  Chemistry       Date:  2017-08-21       Impact factor: 5.236

6.  Cellular responses to Cisplatin-induced DNA damage.

Authors:  Alakananda Basu; Soumya Krishnamurthy
Journal:  J Nucleic Acids       Date:  2010-08-08

7.  Combining Inorganic Chemistry and Biology: The Underestimated Potential of Metal Complexes in Medicine.

Authors:  Johannes Karges
Journal:  Chembiochem       Date:  2020-09-08       Impact factor: 3.164

8.  Partially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection.

Authors:  David G Twigg; Noriyasu Kondo; Sophie L Mitchell; Warren R J D Galloway; Hannah F Sore; Andrew Madin; David R Spring
Journal:  Angew Chem Int Ed Engl       Date:  2016-09-06       Impact factor: 15.336

9.  Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery.

Authors:  Christine N Morrison; Kathleen E Prosser; Ryjul W Stokes; Anna Cordes; Nils Metzler-Nolte; Seth M Cohen
Journal:  Chem Sci       Date:  2019-12-12       Impact factor: 9.969

10.  A Dinuclear Persulfide-Bridged Ruthenium Compound is a Hypoxia-Selective Hydrogen Sulfide (H2 S) Donor.

Authors:  Joshua J Woods; Justin J Wilson
Journal:  Angew Chem Int Ed Engl       Date:  2020-11-16       Impact factor: 15.336

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  1 in total

1.  Engineering cancer cell membrane-camouflaged metal complex for efficient targeting therapy of breast cancer.

Authors:  Xiaoying Li; Yanzi Yu; Qi Chen; Jiabao Lin; Xueqiong Zhu; Xiaoting Liu; Lizhen He; Tianfeng Chen; Weiling He
Journal:  J Nanobiotechnology       Date:  2022-09-05       Impact factor: 9.429

  1 in total

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