Literature DB >> 32896976

Combining Inorganic Chemistry and Biology: The Underestimated Potential of Metal Complexes in Medicine.

Johannes Karges1.   

Abstract

The vast majority of investigated compounds in modern medicine are based on organic molecules. Within the last decades, the field of medicinial chemistry is shifting towards the application of metal complexes. These compounds offer different mechanisms of action in comparison to organic molecules due to their unique properties, making them novel drug candidates. Herein, the successful combination of metal containing compounds and medicine is highlighted by their application for photodynamic therapy.
© 2020 Wiley-VCH GmbH.

Entities:  

Keywords:  anticancer; bioinorganic chemistry; medicinal inorganic chemistry; metals in medicine; photodynamic therapy

Mesh：

Substances：

Year:  2020        PMID： 32896976     DOI： 10.1002/cbic.202000397

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  7 in total

Review 1.  Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy.

Authors:  Johannes Karges; Hui Chao; Gilles Gasser
Journal:  J Biol Inorg Chem       Date:  2020-11-04       Impact factor: 3.358

2.  Metal Complexes for Therapeutic Applications.

Authors:  Johannes Karges; Ryjul W Stokes; Seth M Cohen
Journal:  Trends Chem       Date:  2021-04-14

Review 3.  Metal Complexes as Antiviral Agents for SARS-CoV-2.

Authors:  Johannes Karges; Seth M Cohen
Journal:  Chembiochem       Date:  2021-06-14       Impact factor: 3.461

4.  ReI Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease.

Authors:  Johannes Karges; Mark Kalaj; Milan Gembicky; Seth M Cohen
Journal:  Angew Chem Int Ed Engl       Date:  2021-03-26       Impact factor: 16.823

5.  Aminothiazole-Linked Metal Chelates: Synthesis, Density Functional Theory, and Antimicrobial Studies with Antioxidant Correlations.

Authors:  Sadaf Noreen; Sajjad H Sumrra
Journal:  ACS Omega       Date:  2021-11-24

6.  Interaction of Carrier Protein with Potential Metallic Drug Candidate N-Glycoside 'GATPT': Validation by Multi-Spectroscopic and Molecular Docking Approaches.

Authors:  Sabiha Parveen; Mohd Sajid Ali; Hamad A Al-Lohedan; Sartaj Tabassum
Journal:  Molecules       Date:  2021-11-02       Impact factor: 4.411

7.  Photorelease of a metal-binding pharmacophore from a Ru(II) polypyridine complex.

Authors:  Johannes Karges; Ryjul W Stokes; Seth M Cohen
Journal:  Dalton Trans       Date:  2021-03-02       Impact factor: 4.390
  7 in total

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