APAAACI's activities and this issue.

Recent activities of the Asia Pacific Association of Allergy, Asthma, and Clinical Immunology (APAAACI) are very successful including APAAACI Allergy Week 2022 (16–22 May) with the theme of ‘Climate change a global challenge: impact on allergic diseases.’ APAAACI TV is very active. Especially APAAACI MasterClass/The Junior APAAACI Allergy Leadership Forum Café is really successful and became one of APAAACI’s flagship programs. Motivational conversations with global leaders provide a great motivation and inspiration for our younger generation and all. The latest interview was done with professor You-Young Kim, past president of APAAACI (1998 & 2002–2004), from Korea. Please note and save the date that World Allergy Congress 2022 will be held in Istanbul 13–15 Oct 2022, and that ‘APAAACI 2022 Congress PSAAI@50’ will be held in Manila 5-8 Dec 2022.

World Allergy Week 2022 (5–11 Jun) by the World Allergy Organization was also very successful with the theme of ‘Breathe Better: The Asthma and Allergy Connection – Promoting better breathing begins with understanding how airway allergies are connected.’ It is always important to think about, diagnose, and treat upper airway diseases together when you treat lower airway diseases such as asthma for better treatment outcome. In this issue, readers will find a systematic review on the association of upper airway bacterial microbiota and asthma [1].

Food allergy in Asia and other parts of the world is a topic of great interest. In this issue, Lee et al. [2] report the prevalence of IgE-mediated cow milk, egg and peanut allergy in young Singapore children below 30 months of age. Readers will also find the patterns of allergenic food introduction in Los Angeles inner-city children [3].

Eosinophil plays an important role in allergic or T2 inflammation, and eosinophil-related mediators could be possible biomarkers in allergic diseases. Kim et al. [4] report eosinophil-derived neurotoxin level was increased in school children with allergic disease. Suzuki et al. [5] also report on major basic protein deposited at intramucosal epithelium with eosinophilic chronic rhinosinusitis.

Coronavirus disease 2019 (COVID-19) vaccine related allergic or hypersensitivity reactions are always of concern and interest for allergists. In this issue, Triwatcharikorn et al. [6] report a very interesting case report that delayed localized urticaria developed after BNT162b2 booster vaccination at previous intradermal test site with severe acute respiratory syndrome-coronavirus-2 spike protein. Readers will also find a case report of Stevens-Johnson Syndrome related with Comirnaty® Covid-19 Vaccine [7].

Marques et al. [8] report the clinical and genetic features of systemic autoinflammatory diseases that are monogenic and polygenic inherited conditions characterized by dysregulation of the innate immune system. Readers will also find an original article on the association of CD4 lymphocyte count with drug hypersensitivity reaction to highly active antiretroviral therapy, trimethoprim sulfamethoxazole and antitubercular agents in human immunodeficiency virus patients, and a pediatric case of exercise-augmented anaphylaxis followed by bee-pollen ingestion [910].