| Literature DB >> 35895363 |
Tereza Magalhaes1,2, Clarice N L Morais3, Elisa A N Azevedo3, Iracema J A A Jacques3, Priscila M S Castanha4,5, Marli T Cordeiro3, Cynthia Braga6, Thomas Jaenisch7,8, Ernesto T A Marques4, Brian D Foy2.
Abstract
It is currently not clear whether humoral immunity to Zika virus (ZIKV) elicited upon natural ZIKV infection is long-lasting. In addition, cross-reactivity of anti-ZIKV antibodies with antigenically related dengue viruses (DENV) may have biological implications in nonnaive individuals who subsequently acquire a heterotypic infection. Cross-reactive humoral immunity between ZIKV and DENV also complicates the interpretation of serological tests to evaluate previous exposure to either virus. Here, we have measured the 2-year decay of ZIKV neutralizing antibodies in people living in a ZIKV/DENV endemic area in Brazil who were identified as having an acute infection (group 1) or past (but recent) infection (group 2) with ZIKV in 2015-16. The titers of neutralizing antibodies to ZIKV decreased 9.1 and 2.3 times in groups 1 and 2, respectively. We also show that the plaque reduction neutralization assay (PRNT) is a reliable method to measure past exposure to ZIKV in coendemic areas.Entities:
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Year: 2022 PMID： 35895363 PMCID： PMC9294702 DOI： 10.4269/ajtmh.21-1279
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 3.707