INTRODUCTION: : A Zika virus epidemic was registered in 2015 in Northeast Brazil. In the State of Pernambuco, thousands of classical cases transpired, and in the following months, neurological disturbances in adults and microcephaly in newborns emerged as complications. After the peak of the epidemic, the official system reported only four cases of Zika virus but over 100,000 cases of dengue virus. The vigilance system was unable to retrospectively estimate cases or to issue an alert to officially notified cases with possible inconsistence concerning specific arbovirosis diagnoses. METHODS: : To evaluate the frequency of different arbovirosis diagnoses based on clinical-epidemiologic criteria, from January to April 2015, we conducted a hospital-based cross-sectional study retrospectively analyzing suspected cases of arbovirosis. RESULTS: : Of 1 , 046 total suspected cases of arbovirus, 895 (86%) were classified as probable Zika virus cases, and 151 (14%) as probable dengue virus cases. The most frequent manifestations in probable Zika virus cases were exanthema (100%), pruritus (50.7%), fever (20.4%) and arthralgia (27.7%). CONCLUSIONS: : In contrast to the official data, during the peak months of the arbovirosis epidemic of 2015, most cases were compatible with Zika virus infections. Hospital-based studies, although retrospective and based on secondary data from clinical files, might provide a better estimate of the number of cases relative to currently available data, if derived from several urgent care units of representative areas of a city or state.This would partially retrospectively correct some inconsistences regarding official notifications.
INTRODUCTION: : A Zika virus epidemic was registered in 2015 in Northeast Brazil. In the State of Pernambuco, thousands of classical cases transpired, and in the following months, neurological disturbances in adults and microcephaly in newborns emerged as complications. After the peak of the epidemic, the official system reported only four cases of Zika virus but over 100,000 cases of dengue virus. The vigilance system was unable to retrospectively estimate cases or to issue an alert to officially notified cases with possible inconsistence concerning specific arbovirosis diagnoses. METHODS: : To evaluate the frequency of different arbovirosis diagnoses based on clinical-epidemiologic criteria, from January to April 2015, we conducted a hospital-based cross-sectional study retrospectively analyzing suspected cases of arbovirosis. RESULTS: : Of 1 , 046 total suspected cases of arbovirus, 895 (86%) were classified as probable Zika virus cases, and 151 (14%) as probable dengue virus cases. The most frequent manifestations in probable Zika virus cases were exanthema (100%), pruritus (50.7%), fever (20.4%) and arthralgia (27.7%). CONCLUSIONS: : In contrast to the official data, during the peak months of the arbovirosis epidemic of 2015, most cases were compatible with Zika virus infections. Hospital-based studies, although retrospective and based on secondary data from clinical files, might provide a better estimate of the number of cases relative to currently available data, if derived from several urgent care units of representative areas of a city or state.This would partially retrospectively correct some inconsistences regarding official notifications.
Authors: Matthew T Aliota; Leda Bassit; Shelton S Bradrick; Bryan Cox; Mariano A Garcia-Blanco; Christina Gavegnano; Thomas C Friedrich; Thaddeus G Golos; Diane E Griffin; Andrew D Haddow; Esper G Kallas; Uriel Kitron; Marc Lecuit; Diogo M Magnani; Caroline Marrs; Natalia Mercer; Edward McSweegan; Lisa F P Ng; David H O'Connor; Jorge E Osorio; Guilherme S Ribeiro; Michael Ricciardi; Shannan L Rossi; George Saade; Raymond F Schinazi; Geraldine O Schott-Lerner; Chao Shan; Pei-Yong Shi; David I Watkins; Nikos Vasilakis; Scott C Weaver Journal: Antiviral Res Date: 2017-06-06 Impact factor: 5.970
Authors: Tereza Magalhaes; Clarice N L Morais; Elisa A N Azevedo; Iracema J A A Jacques; Priscila M S Castanha; Marli T Cordeiro; Cynthia Braga; Thomas Jaenisch; Ernesto T A Marques; Brian D Foy Journal: Am J Trop Med Hyg Date: 2022-06-06 Impact factor: 3.707
Authors: Wanderson K de Oliveira; Eduardo H Carmo; Claudio M Henriques; Giovanini Coelho; Enrique Vazquez; Juan Cortez-Escalante; Joaquin Molina; Sylvain Aldighieri; Marcos A Espinal; Christopher Dye Journal: N Engl J Med Date: 2017-03-29 Impact factor: 91.245
Authors: Anita Ramesh; Claire L Jeffries; Priscila Castanha; Paula A S Oliveira; Neal Alexander; Mary Cameron; Cynthia Braga; Thomas Walker Journal: Wellcome Open Res Date: 2019-06-10
Authors: Tereza Magalhaes; Cynthia Braga; Marli T Cordeiro; Andre L S Oliveira; Priscila M S Castanha; Ana Paula R Maciel; Nathalia M L Amancio; Pollyanne N Gouveia; Valter J Peixoto-da-Silva; Thaciana F L Peixoto; Helena Britto; Priscilla V Lima; Andreza R S Lima; Kerstin D Rosenberger; Thomas Jaenisch; Ernesto T A Marques Journal: PLoS Negl Trop Dis Date: 2017-11-06
Authors: Elzinandes Leal Azeredo; Flavia Barreto Dos Santos; Luciana Santos Barbosa; Thiara Manuele Alves Souza; Jessica Badolato-Corrêa; Juan Camilo Sánchez-Arcila; Priscila Conrado Guerra Nunes; Luzia Maria de-Oliveira-Pinto; Ana Maria de Filippis; Márcia Dal Fabbro; Izilyanne Hoscher Romanholi; Rivaldo Venancio da Cunha Journal: PLoS Curr Date: 2018-02-15