Literature DB >> 35895355

Case Report: Chemoradiation with Paclitaxel and Carboplatin Unveiling Leprosy Type 1 Downgrading Reaction.

B Savitha1, Kabir Sardana1, Ananta Khurana1, Seema Rani1, Soumya Sachdeva1, Arvind Ahuja2.   

Abstract

Type 1 lepra reaction (T1R) is a major complication seen in nonpolar forms of leprosy and leads to significant morbidity. The classification of T1R as up and downgrading, based on previously defined histopathological criteria (by Ridley), has therapeutic and prognostic implications. The trigger factors for these reactions are poorly described, especially in case of downgrading T1R and we describe a case of leprosy reaction that was possibly triggered by chemoradiation and elucidate the possible mechanism.

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Year:  2022        PMID: 35895355      PMCID: PMC9294680          DOI: 10.4269/ajtmh.22-0099

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN: 0002-9637            Impact factor:   3.707


  11 in total

Review 1.  Abscopal effects of radiation therapy: a clinical review for the radiobiologist.

Authors:  Shankar Siva; Michael P MacManus; Roger F Martin; Olga A Martin
Journal:  Cancer Lett       Date:  2013-10-12       Impact factor: 8.679

Review 2.  Chemotherapy-induced immunomodulation in non-small-cell lung cancer: a rationale for combination chemoimmunotherapy.

Authors:  Hua Zheng; Masha Zeltsman; Marjorie G Zauderer; Takashi Eguchi; Raj G Vaghjiani; Prasad S Adusumilli
Journal:  Immunotherapy       Date:  2017-09       Impact factor: 4.196

3.  Development of leprosy and type 1 leprosy reactions after treatment with infliximab: a report of 2 cases.

Authors:  D M Scollard; M P Joyce; T P Gillis
Journal:  Clin Infect Dis       Date:  2006-06-09       Impact factor: 9.079

4.  Multidrug resistance as a cause of steroid-nonresponsive downgrading type I reaction in Hansen's disease.

Authors:  Surabhi Sinha; Kabir Sardana; Diksha Agrawal; Purnima Malhotra; Mallika Lavania; Madhvi Ahuja
Journal:  Int J Mycobacteriol       Date:  2019 Jul-Sep

Review 5.  Leprosy and HIV coinfection: a critical approach.

Authors:  Cesare Massone; Carolina Talhari; Rodrigo Ribeiro-Rodrigues; Renata Helena Monteiro Sindeaux; Marcelo Távora Mira; Sinesio Talhari; Bernard Naafs
Journal:  Expert Rev Anti Infect Ther       Date:  2011-06       Impact factor: 5.091

6.  Emergence of leprosy in a patient with mycosis fungoides.

Authors:  D Grossman; R P Rapini; B Osborne; M Duvic
Journal:  J Am Acad Dermatol       Date:  1994-02       Impact factor: 11.527

7.  The histological course of reactions in borderline leprosy and their outcome.

Authors:  D S Ridley; K B Radia
Journal:  Int J Lepr Other Mycobact Dis       Date:  1981-12

8.  Effects of conventional therapeutic interventions on the number and function of regulatory T cells.

Authors:  Mario Roselli; Vittore Cereda; Maria Giovanna di Bari; Vincenzo Formica; Antonella Spila; Caroline Jochems; Benedetto Farsaci; Renee Donahue; James L Gulley; Jeffrey Schlom; Fiorella Guadagni
Journal:  Oncoimmunology       Date:  2013-10-01       Impact factor: 8.110

9.  In situ T regulatory cells and Th17 cytokines in paired samples of leprosy type 1 and type 2 reactions.

Authors:  Maurício Barcelos Costa; Emerith Mayra Hungria; Aline Araújo Freitas; Ana Lúcia O M Sousa; Juliano Jampietro; Fernando A Soares; Mariane M A Stefani
Journal:  PLoS One       Date:  2018-06-08       Impact factor: 3.240

10.  Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6.

Authors:  Chaman Saini; Anisuddin Siddiqui; Venkatesh Ramesh; Indira Nath
Journal:  PLoS Negl Trop Dis       Date:  2016-04-01
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