| Literature DB >> 35894117 |
Prakash Gangadaran1,2, Himabindu Padinjarathil3,4, Shri Hari Subhashri Rajendran5, Manasi P Jogalekar6, Chae Moon Hong2, Baladhandapani Aruchamy3,4, Uma Maheswari Rajendran7, Sridharan Gurunagarajan8, Anand Krishnan9, Prasanna Ramani3,4, Kavimani Subramanian5.
Abstract
Coronavirus disease 2019 (COVID-19) management has been challenging for patients with comorbidities. Patients with diabetes and COVID-19, in particular, have shown severe symptoms and rapid progression of the disease. They also have a high mortality rate compared to the non-diabetic population. The high mortality rate is caused in people with diabetes who are in a pro-inflammatory condition; this could worsen COVID-19. In addition, people with diabetes have circulatory issues and COVID-19 infection can lead to further clotting problems. It is critical to understand the mechanisms underlying the adverse clinical outcomes in patients with diabetes and COVID-19. This review discusses various disease conditions contributing to poor prognosis in diabetic COVID-19 patients such as hyperglycemia, insulin resistance, impaired pancreatic function, and production of advanced glycation end products.Entities:
Keywords: COVID-19; SARS-CoV-2; diabetics; hyperglycemia; insulin resistance
Mesh：
Year: 2022 PMID： 35894117 PMCID： PMC9442454 DOI： 10.1177/15353702221108914
Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699