Background: Although numerous studies have investigated obesity's negative effect on coronavirus disease 2019 (COVID-19) outcomes, only a limited number focused on this association in diabetic patients. In this study, we analyzed the association between obesity and COVID-19 outcome (death, intensive care unit [ICU] admission, mechanical ventilation needs, quick Sequential Organ Failure Assessment [qSOFA] score, and confusion, urea, respiratory rate, blood pressure [CURB-65] scores) for hospitalized diabetic patients. Methods: In this prospective hospital-based registry of patients with COVID-19 in East Azerbaijan, Iran, 368 consecutive diabetic patients with COVID-19 were followed from admission until discharge or death. Self-reported weight and height were used to calculate body mass index (kg/m2) upon admission. Our primary endpoint was analyzing obesity and COVID-19 mortality association. Assessing the associations among obesity and disease severity, ICU admission, and mechanical ventilation was our secondary endpoint. Results: We analyzed data from 317 patients and found no significant difference between obese and non-obese patients regarding frequency of death, invasive mechanical ventilation, ICU admission, CURB-65, or qSOFA scores (P<0.05). After adjusting for confounding factors, obese diabetic COVID-19 patients were 2.72 times more likely to die than non-obese patients. Moreover, ventilator dependence (adjusted odds ratio [aOR], 1.87; 95% confidence interval [CI], 1.03-4.76) and ICU admission (aOR, 2.41; 95% CI, 1.11-5.68) odds were significantly higher for obese patients than non-obese patients. Conclusion: The results of the present study indicated that obesity worsens health outcomes for diabetic COVID-19 patients.
Background: Although numerous studies have investigated obesity's negative effect on coronavirus disease 2019 (COVID-19) outcomes, only a limited number focused on this association in diabeticpatients. In this study, we analyzed the association between obesity and COVID-19 outcome (death, intensive care unit [ICU] admission, mechanical ventilation needs, quick Sequential Organ Failure Assessment [qSOFA] score, and confusion, urea, respiratory rate, blood pressure [CURB-65] scores) for hospitalized diabeticpatients. Methods: In this prospective hospital-based registry of patients with COVID-19 in East Azerbaijan, Iran, 368 consecutive diabeticpatients with COVID-19 were followed from admission until discharge or death. Self-reported weight and height were used to calculate body mass index (kg/m2) upon admission. Our primary endpoint was analyzing obesity and COVID-19mortality association. Assessing the associations among obesity and disease severity, ICU admission, and mechanical ventilation was our secondary endpoint. Results: We analyzed data from 317 patients and found no significant difference between obese and non-obesepatients regarding frequency of death, invasive mechanical ventilation, ICU admission, CURB-65, or qSOFA scores (P<0.05). After adjusting for confounding factors, obese diabetic COVID-19patients were 2.72 times more likely to die than non-obesepatients. Moreover, ventilator dependence (adjusted odds ratio [aOR], 1.87; 95% confidence interval [CI], 1.03-4.76) and ICU admission (aOR, 2.41; 95% CI, 1.11-5.68) odds were significantly higher for obesepatients than non-obesepatients. Conclusion: The results of the present study indicated that obesity worsens health outcomes for diabetic COVID-19patients.
Entities:
Keywords:
COVID-19; Death; Diabetes mellitus; Intensive care units; Obesity
Authors: Dae-Kyum Kim; Benjamin Weller; Chung-Wen Lin; Dayag Sheykhkarimli; Jennifer J Knapp; Guillaume Dugied; Andreas Zanzoni; Carles Pons; Marie J Tofaute; Sibusiso B Maseko; Kerstin Spirohn; Florent Laval; Luke Lambourne; Nishka Kishore; Ashyad Rayhan; Mayra Sauer; Veronika Young; Hridi Halder; Nora Marín-de la Rosa; Oxana Pogoutse; Alexandra Strobel; Patrick Schwehn; Roujia Li; Simin T Rothballer; Melina Altmann; Patricia Cassonnet; Atina G Coté; Lena Elorduy Vergara; Isaiah Hazelwood; Betty B Liu; Maria Nguyen; Ramakrishnan Pandiarajan; Bushra Dohai; Patricia A Rodriguez Coloma; Juline Poirson; Paolo Giuliana; Luc Willems; Mikko Taipale; Yves Jacob; Tong Hao; David E Hill; Christine Brun; Jean-Claude Twizere; Daniel Krappmann; Matthias Heinig; Claudia Falter; Patrick Aloy; Caroline Demeret; Marc Vidal; Michael A Calderwood; Frederick P Roth; Pascal Falter-Braun Journal: Nat Biotechnol Date: 2022-10-10 Impact factor: 68.164