Literature DB >> 3589000

The effects of dose-fractionation on radiation-induced heart disease in rats.

S Lauk, S Rüth, K R Trott.   

Abstract

The hearts of Wistar rats were irradiated locally with a range of total doses given in 1, 3, 5 or 10 fractions in 4 weeks. As even after the lowest single dose of 17.5 Gy all animals died within 18 months after irradiation from heart failure, no ED50 could be determined. Therefore, the mean survival time following irradiation was chosen as isoeffect for the comparison of different treatment groups. Fractionation has a marked sparing effect on the radiation-induced heart disease. For an isoeffect of a mean survival time of 42 weeks an alpha/beta of 1 Gy was found.

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Mesh：

Year:  1987        PMID： 3589000     DOI： 10.1016/s0167-8140(87)80187-1

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN： 0167-8140            Impact factor:   6.280


  5 in total

Review 1.  Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms.

Authors:  M P Little; E J Tawn; I Tzoulaki; R Wakeford; G Hildebrandt; F Paris; S Tapio; P Elliott
Journal:  Radiat Environ Biophys       Date:  2009-10-28       Impact factor: 1.925

2.  Hypo- vs. normofractionated radiation therapy in breast cancer: A patterns of care analysis in German speaking countries.

Authors:  M Mayinger; C Straube; D Habermehl; M N Duma; S E Combs
Journal:  Rep Pract Oncol Radiother       Date:  2020-07-28

Review 3.  All for one, though not one for all: team players in normal tissue radiobiology.

Authors:  Marjan Boerma; Catherine M Davis; Isabel L Jackson; Dörthe Schaue; Jacqueline P Williams
Journal:  Int J Radiat Biol       Date:  2021-07-01       Impact factor: 2.694

Review 4.  Heart toxicity from breast cancer radiotherapy : Current findings, assessment, and prevention.

Authors:  Marc D Piroth; René Baumann; Wilfried Budach; Jürgen Dunst; Petra Feyer; Rainer Fietkau; Wulf Haase; Wolfgang Harms; Thomas Hehr; David Krug; Arnd Röser; Felix Sedlmayer; Rainer Souchon; Frederik Wenz; Rolf Sauer
Journal:  Strahlenther Onkol       Date:  2018-10-11       Impact factor: 3.621

5.  A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure.

Authors:  Mark P Little; Anna Gola; Ioanna Tzoulaki
Journal:  PLoS Comput Biol       Date:  2009-10-23       Impact factor: 4.475
  5 in total

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