Literature DB >> 3588287

A new 'sense' RNA approach to block viral RNA replication in vitro.

M D Morch, R L Joshi, T M Denial, A L Haenni.   

Abstract

The use of "antisense" RNA is being widely considered to block specific steps in viral infection. We propose here a new "sense" RNA approach to block viral RNA replication in vitro and possibly in vivo. In the turnip yellow mosaic virus (TYMV) system, the recognition site of the viral replicase (RNA-dependent RNA polymerase) is assumed to be located within the 3' end of the RNA genome. Small "sense" RNAs have been obtained by in vitro transcription of the corresponding cloned cDNAs. Replication of TYMV RNA in vitro is shown here to be blocked only by those RNAs that contain the 3' terminal region of the genome.

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Year:  1987        PMID： 3588287      PMCID： PMC340836          DOI： 10.1093/nar/15.10.4123

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  22 in total

1.  Sequence homology adjacent to the 3' terminal poly(A) of cowpea mosaic virus RNAs.

Authors:  J W Davies; J Stanley; A Van Kammen
Journal:  Nucleic Acids Res       Date:  1979-09-25       Impact factor: 16.971

2.  Presence of a large poly(rC) tract within the RNA of encephalomyocarditis virus.

Authors:  A Porter; N Carey; P Fellner
Journal:  Nature       Date:  1974-04-19       Impact factor: 49.962

3.  Nucleotide sequence of the 3'-noncoding region of alfalfa mosaic virus RNA 4 and its homology with the genomic RNAs.

Authors:  E C Koper-Zwarthoff; F T Brederode; P Walstra; J F Bol
Journal:  Nucleic Acids Res       Date:  1979-12-11       Impact factor: 16.971

Review 4.  tRNA-like structures in the genomes of RNA viruses.

Authors:  A L Haenni; S Joshi; F Chapeville
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1982

5.  Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

Authors:  P C Zamecnik; M L Stephenson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

6.  Near identity of 3- RNA secondary structure in bromoviruses and cucumber mosaic virus.

Authors:  P Ahlquist; R Dasgupta; P Kaesberg
Journal:  Cell       Date:  1981-01       Impact factor: 41.582

7.  The isolation of plant viruses by means of "simple" coacervates.

Authors:  R Leberman
Journal:  Virology       Date:  1966-11       Impact factor: 3.616

8.  Nucleotide sequence of the 3'-terminal tRNA-like structure in barley stripe mosaic virus genome.

Authors:  V V Rupasov; D M Adyshev; S N Belgelarskaya; A A Agranovsky; A S Mankin; V V Dolja; J G Atabekov
Journal:  Nucleic Acids Res       Date:  1984-05-11       Impact factor: 16.971

9.  RNA 2 of tobacco rattle virus strain TCM encodes an unexpected gene.

Authors:  G C Angenent; H J Linthorst; A F van Belkum; B J Cornelissen; J F Bol
Journal:  Nucleic Acids Res       Date:  1986-06-11       Impact factor: 16.971

10.  The virulent satellite RNA of turnip crinkle virus has a major domain homologous to the 3' end of the helper virus genome.

Authors:  A E Simon; S H Howell
Journal:  EMBO J       Date:  1986-12-20       Impact factor: 11.598
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  9 in total

1.  The role of the pseudoknot at the 3' end of turnip yellow mosaic virus RNA in minus-strand synthesis by the viral RNA-dependent RNA polymerase.

Authors:  B A Deiman; R M Kortlever; C W Pleij
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  Inhibition of gene expression by a short sense fragment.

Authors:  F H Cameron; P A Jennings
Journal:  Nucleic Acids Res       Date:  1991-02-11       Impact factor: 16.971

3.  In vitro transcription by the turnip yellow mosaic virus RNA polymerase: a comparison with the alfalfa mosaic virus and brome mosaic virus replicases.

Authors:  B A Deiman; P W Verlaan; C W Pleij
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

4.  Minimal template requirements for initiation of minus-strand synthesis in vitro by the RNA-dependent RNA polymerase of turnip yellow mosaic virus.

Authors:  B A Deiman; A K Koenen; P W Verlaan; C W Pleij
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

Review 5.  Strategies to protect crop plants against viruses: pathogen-derived resistance blossoms.

Authors:  T M Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

6.  Co-suppression mediated virus resistance in transgenic tobacco plants harboring the 3'-untranslated region of Andean potato mottle virus.

Authors:  M F Vaslin; M S Vidal; E D Alves; L Farinelli; D E de Oliveira
Journal:  Transgenic Res       Date:  2001-12       Impact factor: 2.788

7.  Inhibition of human immunodeficiency virus type 1 multiplication by antisense and sense RNA expression.

Authors:  S Joshi; A Van Brunschot; S Asad; I van der Elst; S E Read; A Bernstein
Journal:  J Virol       Date:  1991-10       Impact factor: 5.103

Review 8.  Comparison of the replication of positive-stranded RNA viruses of plants and animals.

Authors:  K W Buck
Journal:  Adv Virus Res       Date:  1996       Impact factor: 9.937

Review 9.  The TYMV tRNA-like structure.

Authors:  R Giegé; C Florentz; T W Dreher
Journal:  Biochimie       Date:  1993       Impact factor: 4.079
  9 in total

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