Literature DB >> 3587615

Oxytocin in Alzheimer's disease: postmortem brain levels.

M F Mazurek, M F Beal, E D Bird, J B Martin.   

Abstract

Oxytocin (OXY) injected into the hippocampus is reported to interfere with the formation of memory in experimental animals. Memory impairment is one of the distinguishing features of Alzheimer's disease. We have studied OXY immunoreactivity in postmortem brain tissue from 12 cases of histologically confirmed Alzheimer's disease and 13 controls. OXY concentration was increased 33% in the hippocampus and temporal cortex of Alzheimer brains (p less than 0.05), but normal in all other regions examined. Elevated hippocampal OXY levels may contribute to the memory disturbance associated with Alzheimer's disease.

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Year:  1987        PMID： 3587615     DOI： 10.1212/wnl.37.6.1001

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  10 in total

1.  Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.

Authors:  Didem Pehlivanoglu; Elisha Myers; Natalie C Ebner
Journal:  Biol Psychol       Date:  2020-06-05       Impact factor: 3.251

2.  DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.

Authors:  Andy Madrid; Kirk J Hogan; Ligia A Papale; Lindsay R Clark; Sanjay Asthana; Sterling C Johnson; Reid S Alisch
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

3.  Comprehensive annotation of microRNA expression profiles.

Authors:  Bo Sun; Fei Yang; Fei-Hu Hu; Ning-Ping Huang; Zhong-Dang Xiao
Journal:  BMC Genet       Date:  2013-12-20       Impact factor: 2.797

4.  A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes.

Authors:  Fu-Hui Xiao; Yong-Han He; Qi-Gang Li; Huan Wu; Long-Hai Luo; Qing-Peng Kong
Journal:  PLoS One       Date:  2015-03-20       Impact factor: 3.240

Review 5.  The Cholinergic System, the Adrenergic System and the Neuropathology of Alzheimer's Disease.

Authors:  Rola A Bekdash
Journal:  Int J Mol Sci       Date:  2021-01-28       Impact factor: 5.923

Review 6.  Multiple Aspects of Inappropriate Action of Renin-Angiotensin, Vasopressin, and Oxytocin Systems in Neuropsychiatric and Neurodegenerative Diseases.

Authors:  Ewa Szczepanska-Sadowska; Agnieszka Wsol; Agnieszka Cudnoch-Jedrzejewska; Katarzyna Czarzasta; Tymoteusz Żera
Journal:  J Clin Med       Date:  2022-02-09       Impact factor: 4.241

7.  Mining on Alzheimer's diseases related knowledge graph to identity potential AD-related semantic triples for drug repurposing.

Authors:  Yi Nian; Xinyue Hu; Rui Zhang; Jingna Feng; Jingcheng Du; Fang Li; Larry Bu; Yuji Zhang; Yong Chen; Cui Tao
Journal:  BMC Bioinformatics       Date:  2022-09-30       Impact factor: 3.307

8.  β1-adrenergic receptor activation enhances memory in Alzheimer's disease model.

Authors:  Laurence Coutellier; Pooneh Memar Ardestani; Mehrdad Shamloo
Journal:  Ann Clin Transl Neurol       Date:  2014-05-01       Impact factor: 4.511

9.  Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice.

Authors:  Lin Yuan; Song Liu; Xuemei Bai; Yan Gao; Guangheng Liu; Xueer Wang; Dexiang Liu; Tong Li; Aijun Hao; Zhen Wang
Journal:  J Neuroinflammation       Date:  2016-04-13       Impact factor: 8.322

10.  An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.

Authors:  Janou A Y Roubroeks; Adam R Smith; Rebecca G Smith; Ehsan Pishva; Zina Ibrahim; Martina Sattlecker; Eilis J Hannon; Iwona Kłoszewska; Patrizia Mecocci; Hilkka Soininen; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Dag Aarsland; Petroula Proitsi; Angela Hodges; Simon Lovestone; Stephen J Newhouse; Richard J B Dobson; Jonathan Mill; Daniël L A van den Hove; Katie Lunnon
Journal:  Neurobiol Aging       Date:  2020-07-03       Impact factor: 4.673
  10 in total

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