Literature DB >> 30372681

DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.

Andy Madrid1,2, Kirk J Hogan3,4, Ligia A Papale1, Lindsay R Clark4,5,6, Sanjay Asthana5,6, Sterling C Johnson4,5,6, Reid S Alisch1.   

Abstract

Differentially methylated positions (DMPs) between persons with and without late-onset Alzheimer's disease (LOAD) were observed at 477 of 769,190 loci in a plurality of genes. Of these, 17 were shared with DMPs identified using clinical LOAD markers analyzed independently as continuous variables comprising Rey Auditory Verbal Learning Test scores, cerebrospinal fluid total tau (t-tau) and phosphorylated tau 181 (p-tau181) levels, and t-tau/Aβ1-42 (Aβ42), p-tau181/Aβ42, and Aβ42/Aβ1-40 (Aβ40) ratios. In patients with LOAD, 12 of the shared 17 DMPs were hypomethylated in B3GALT4 (Beta-1,3-galatcosyltransferase 4) (EC 2.4.1.62), and 5 were hypomethylated in ZADH2 (Prostaglandin reductase 3) (EC 1.3.1.48).

Entities:  

Keywords:  Amyloid; DNA methylation; late-onset Alzheimer’s disease; tau proteins

Mesh：

Substances：

Year:  2018        PMID： 30372681      PMCID： PMC6478383          DOI： 10.3233/JAD-180592

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  51 in total

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2.  The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.

Authors:  Marilyn S Albert; Steven T DeKosky; Dennis Dickson; Bruno Dubois; Howard H Feldman; Nick C Fox; Anthony Gamst; David M Holtzman; William J Jagust; Ronald C Petersen; Peter J Snyder; Maria C Carrillo; Bill Thies; Creighton H Phelps
Journal:  Alzheimers Dement       Date:  2011-04-21       Impact factor: 21.566

3.  Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease.

Authors:  David C Hondius; Pim van Nierop; Ka Wan Li; Jeroen J M Hoozemans; Roel C van der Schors; Elise S van Haastert; Saskia M van der Vies; Annemieke J M Rozemuller; August B Smit
Journal:  Alzheimers Dement       Date:  2016-01-06       Impact factor: 21.566

4.  Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays.

Authors:  Martin J Aryee; Andrew E Jaffe; Hector Corrada-Bravo; Christine Ladd-Acosta; Andrew P Feinberg; Kasper D Hansen; Rafael A Irizarry
Journal:  Bioinformatics       Date:  2014-01-28       Impact factor: 6.937

5.  Blood DNA methylation as a potential biomarker of dementia: A systematic review.

Authors:  Peter D Fransquet; Paul Lacaze; Richard Saffery; John McNeil; Robyn Woods; Joanne Ryan
Journal:  Alzheimers Dement       Date:  2017-11-08       Impact factor: 21.566

6.  Biochemical maturation of human central nervous system myelin.

Authors:  M A Fishman; H C Agrawal; A Alexander; J Golterman
Journal:  J Neurochem       Date:  1975-04       Impact factor: 5.372

7.  Risk of Alzheimer's disease and duration of NSAID use.

Authors:  W F Stewart; C Kawas; M Corrada; E J Metter
Journal:  Neurology       Date:  1997-03       Impact factor: 9.910

8.  Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis.

Authors:  Lars Bäckman; Sari Jones; Anna-Karin Berger; Erika Jonsson Laukka; Brent J Small
Journal:  Neuropsychology       Date:  2005-07       Impact factor: 3.295

9.  Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research.

Authors:  Esther Walton; Johanna Hass; Jingyu Liu; Joshua L Roffman; Fabio Bernardoni; Veit Roessner; Matthias Kirsch; Gabriele Schackert; Vince Calhoun; Stefan Ehrlich
Journal:  Schizophr Bull       Date:  2015-06-08       Impact factor: 9.306

10.  BECon: a tool for interpreting DNA methylation findings from blood in the context of brain.

Authors:  R D Edgar; M J Jones; M J Meaney; G Turecki; M S Kobor
Journal:  Transl Psychiatry       Date:  2017-08-01       Impact factor: 6.222
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  14 in total

1.  Alzheimer's Disease-Related Genes Identified by Linking Spatial Patterns of Pathology and Gene Expression.

Authors:  Roger Mullins; Dimitrios Kapogiannis
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2.  Blood DNA methylation and COVID-19 outcomes.

Authors:  Joseph Balnis; Andy Madrid; Kirk J Hogan; Lisa A Drake; Hau C Chieng; Anupama Tiwari; Catherine E Vincent; Amit Chopra; Peter A Vincent; Michael D Robek; Harold A Singer; Reid S Alisch; Ariel Jaitovich
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3.  Targeted Metabolomic Analysis in Alzheimer's Disease Plasma and Brain Tissue in Non-Hispanic Whites.

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Review 4.  Epigenetics of Alzheimer's Disease.

Authors:  Matea Nikolac Perkovic; Alja Videtic Paska; Marcela Konjevod; Katarina Kouter; Dubravka Svob Strac; Gordana Nedic Erjavec; Nela Pivac
Journal:  Biomolecules       Date:  2021-01-30

5.  Association of peripheral blood DNA methylation level with Alzheimer's disease progression.

Authors:  Qingqin S Li; Aparna Vasanthakumar; Justin W Davis; Kenneth B Idler; Kwangsik Nho; Jeffrey F Waring; Andrew J Saykin
Journal:  Clin Epigenetics       Date:  2021-10-15       Impact factor: 6.551

6.  Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder.

Authors:  Darina Czamara; Alexa Neufang; Roman Dieterle; Stella Iurato; Janine Arloth; Jade Martins; Marcus Ising; Elisabeth E Binder; Angelika Erhardt
Journal:  Clin Epigenetics       Date:  2022-04-27       Impact factor: 7.259

7.  VEGF-A-related genetic variants protect against Alzheimer's disease.

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8.  An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.

Authors:  Janou A Y Roubroeks; Adam R Smith; Rebecca G Smith; Ehsan Pishva; Zina Ibrahim; Martina Sattlecker; Eilis J Hannon; Iwona Kłoszewska; Patrizia Mecocci; Hilkka Soininen; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Dag Aarsland; Petroula Proitsi; Angela Hodges; Simon Lovestone; Stephen J Newhouse; Richard J B Dobson; Jonathan Mill; Daniël L A van den Hove; Katie Lunnon
Journal:  Neurobiol Aging       Date:  2020-07-03       Impact factor: 4.673

9.  Epigenome-wide analyses identify DNA methylation signatures of dementia risk.

Authors:  Rosie M Walker; Mairead L Bermingham; Kadi Vaher; Stewart W Morris; Toni-Kim Clarke; Andrew D Bretherick; Yanni Zeng; Carmen Amador; Konrad Rawlik; Kalyani Pandya; Caroline Hayward; Archie Campbell; David J Porteous; Andrew M McIntosh; Riccardo E Marioni; Kathryn L Evans
Journal:  Alzheimers Dement (Amst)       Date:  2020-08-10

Review 10.  DNA Methylation: A Promising Approach in Management of Alzheimer's Disease and Other Neurodegenerative Disorders.

Authors:  Gagandeep Kaur; Suraj Singh S Rathod; Mohammed M Ghoneim; Sultan Alshehri; Javed Ahmad; Awanish Mishra; Nabil A Alhakamy
Journal:  Biology (Basel)       Date:  2022-01-07
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